Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Aboriginal Peoples' Health / Santé des Autochtones
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LAVOIE, Josée G
University of Northern British Columbia BROWNE, Annette J / ENI, Rachel / KAUFERT, Joseph M / O'NEIL, John D
 $132,504 ABH 3 Yr(s)
Leaving for the city: An assessment of cultural social, health and economic dimensions of Manitoba First Nations relocating to urban centres to access medical care
SMYLIE, Janet K
St. Michael's Hospital (Toronto) ABONYI, Sylvia / ANDERSON, Marcia J / BURNS, Roberta Z / CAMPBELL, Maria / DEWAR, Jonathan / MACDOUGALL, Brenda / MARACLE, Sylvia / MCSHANE, Kelly / O'CAMPO, Patricia / STERLING, Lisa S / WHEELER, Winona L / WOLFE, Sara H
 $186,638 ABH 5 Yr(s)
Indigenous Knowledge Network for Infant, Child, and Family Health
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
1
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Aging / Vieillissement
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BETTS, Dean H
University of Guelph MADAN, Pavneesh $111,636 BCA 4 Yr(s)
The role of p66Shc in ROS-mediated cellular senescence
CARPENTIER, Normand C
Institut universitaire de gériatrie de Montréal BERNARD, Paul / GRENIER, Amanda M / GUBERMAN, Nancy / KERGOAT, Marie- Jeanne
 $60,000 SDA 3 Yr(s)
Using the Life Course Perspective to plan interventions among families of people with Alzheimer's disease
FELDMAN, Howard
MACKENZIE, Ian R HALLAM, Bradley J / HSIUNG, Ging-Yuek R / JACOVA, Claudia / RABHERU, Kiran / RUTH, Thomas J / STOESSL, A. Jonathan
 $317,108 BCA 5 Yr(s)
University of British Columbia
Frontotemporal Lobar Degeneration with Ubiquitinated Inclusions: Genetic, Clinical, Pathological and Biomarker Studies
FERNANDES, Karl J
Université de Montréal $98,343 BCA 3 Yr(s)
Neural precursors during aging and Alzheimer's Disease
GRAY, Douglas A
Ottawa Health Research Institute $82,001 BCA 3 Yr(s)
Refinement of a computer model of protein degradation and aging using a well characterized molecular circuit
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
2
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Aging / Vieillissement
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
KIM, Peter C
Hospital for Sick Children (Toronto) $129,363 BCA 4 Yr(s)
Models and Mechanisms of Accelerated Ageing: P63 Regulation of Progenitor Cells and Cellular Senescence in Intestine
LAI, Daniel W
O'CONNOR, Deborah
ANDRUSKE, Cynthia L / CHAN, Sing Mei / DONNELLY, Tam T / SUROOD, Shireen
 $73,708 SDA 3 Yr(s)
University of Calgary
Multicultural perspectives of family caregiving for the aging population
LEROUX, Jean-Christophe
Université de Montréal $83,177 PS 4 Yr(s)
In situ-forming implants of rivastigmine in the treatment of Alzheimer's disease
MONTPLAISIR, Jacques Y
GAGNON, Jean-François MONCHI, Oury / POSTUMA, Ronald B / SOUCY, Jean-Paul
 $127,558 BSC 5 Yr(s)
Hôpital du Sacré-Coeur de Montréal
Diagnostic, pathophysiologie et traitement du trouble comportemental en sommeil paradoxal
PARADIS, Hélène
GENDRON, Robert L $121,612 BCA 4 Yr(s)
Memorial University of Newfoundland
Tubedown in vision loss during aging and age- related retinopathies
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
3
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Aging / Vieillissement
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
RIABOWOL, Karl T
University of Calgary $158,573 BCA 5 Yr(s)
The Role of Lamins in ING Family Function
SEVIGNY, Andrée
AUBIN, Michèle DUMONT, Serge / GUIRGUIS-YOUNGER, Manal / TOURIGNY, André
 $74,834 PLC 3 Yr(s)
Université Laval
L'étude dynamique des facteurs facilitant et contraignant le bénévolat auprès des aînés en fin de vie qui vivent à domicile
SLED, John G
Hospital for Sick Children (Toronto) HENKELMAN, R. Mark $96,620 MPI 3 Yr(s)
Cerebral vascular degeneration
SMITH, Carlyle T
Trent University (Peterborough, Ontario) FELDMAN, Howard / PETERS, Kevin R
 $76,103 BCA 5 Yr(s)
Sleep states, memory and aging
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
4
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ALIBHAI, Shabbir M
University Health Network (Toronto) GUPTA, Vikas $107,500 PSD 3 Yr(s)
A comprehensive study of quality of life and fatigue in AML
AUTEXIER, Chantal
Jewish General Hospital (Montreal) $121,604 BMB 5 Yr(s)
Telomerase Structure and Function
BAXTER, Nancy N
St. Michael's Hospital (Toronto) DEL GIUDICE, Lisa M / PASZAT, Lawrence(Larry) F / RABENECK, Linda / SUTRADHAR, Rinku / URBACH, David R
 $118,418 POP 3 Yr(s)
The Young Adult Survivors of Cancer Study
BEATTIE, Tara L
University of Calgary LEES-MILLER, Susan P $116,745 CBT 3 Yr(s)
Functional Role of hTR/DNA-PK interactions in telomere length maintenace
BEAUCHEMIN, Nicole
McGill University $177,253 CPT 4 Yr(s)
CEACAM1 in colon cancer progression
BROOKS-WILSON, Angela R
University of British Columbia CONNORS, Joseph / GASCOYNE, Randy D / SPINELLI, John Joseph
 $152,409 G 5 Yr(s)
B.C. Cancer Research Centre (Vancouver)
Population-Based Genetics of Non-Hodgkin Lymphoma
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
5
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
CHOY, Wing-Yiu
University of Western Ontario $127,882 BMA 5 Yr(s)
Structural studies of intrinsically disordered proteins
DAY, Robert
Université de Sherbrooke NEUGEBAUER, Witold A
 $134,550 E 3 Yr(s)
PACE4 and prostate cancer
DENAULT, Jean-Bernard
Université de Sherbrooke $110,888 BMA 5 Yr(s)
Mécanismes d'activation des caspases apoptotiques
DENNIS, James W
Mount Sinai Hospital (Toronto) $129,000 MCC 5 Yr(s)
A systems approach to metabolic regulation of cancer growth
DIMITROULAKOS, Jim
Ottawa Health Research Institute $121,949 CBT 3 Yr(s)
Evaluating statins and receptor tyrosine kinase inhibitors as a novel combinational anti-cancer therapeutic approach
DIRKS, Peter B
Hospital for Sick Children (Toronto) $101,166 MCC 5 Yr(s)
Asymmetrical self renewal in normal and cancer stem cells of the human brain
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
6
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
EAVES, Connie J
University of British Columbia $142,609 DEV 3 Yr(s)
B.C. Cancer Research Centre (Vancouver)
Characterization of Human Mammary Epithelial Stem Cells.
EZZAT, Shereen Z
University Health Network (Toronto) ASA, Sylvia L $140,567 CPT 5 Yr(s)
Fibroblast Growth Factor Receptor 2 In Normal and Cancer Cells
FENSTER, Aaron
Robarts Research Institute - U.W.O. (London, Ont.)
 CHIN, Joseph L / IZAWA, Jonathan I / MCKENZIE, Charles A
 $122,366 MPI 5 Yr(s)
University of Western Ontario
3D transrectal ultrasound-guided prostate biopsy
FRADET, Yves
Université Laval BERGERON, Alain / DE CAMPOS LIMA, Pedro O / LACOMBE, Louis / LARUE, Hélène
 $127,021 CBT 3 Yr(s)
Centre de recherche de L'Hôtel-Dieu de Québec
Cancer testis antigen-based immunotherapy of bladder cancer
FRADIN, Cecile
McMaster University $122,550 BMA 5 Yr(s)
The structural basis for Bax-induced membrane permeabilization during apoptosis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
7
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
GASCOYNE, Randy D
University of British Columbia CONNORS, Joseph / STEIDL, Christian
 $130,317 CBT 3 Yr(s)
BC Cancer Agency (Vancouver, BC)
Predicting treatment response in Hodgkin Lymphoma by identifying new molecular markers
GRATTON, Jean-Philippe
Institut de recherches cliniques de Montréal $103,476 MCC 5 Yr(s)
Molecular basis of tumor vessels hyperpermeability
KAY, Robert J
University of British Columbia CORNELL, Rosemary B $114,047 CBM 3 Yr(s)
B.C. Cancer Research Centre (Vancouver)
Membrane-specific targeting of RasGRPs: Mechanisms and consequences
KORNELUK, Robert G
Children's Hospital of Eastern Ontario (Ottawa)
 $170,662 MCC 3 Yr(s)
The role of the Inhibitors of Apoptosis (IAPs) in cancer
LECLAIR, Robert
Laurentian University of Sudbury $58,786 MPI 3 Yr(s)
An energy dispersive x-ray diffraction tool to diagnose cancers in breast biopsies
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
8
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LECOMTE, Roger
Université de Sherbrooke BENARD, Francois / BENTOURKIA, M'Hamed
 $107,289 MPI 5 Yr(s)
Imagerie moléculaire multimodale à haute résolution sur modèle animal: un nouvel outil polyvalent pour la recherche biomédicale
LEE, Patrick W
Dalhousie University (Nova Scotia) $142,330 VVP 5 Yr(s)
The Molecular Basis of Host Cell Permissiveness to Reovirus Infection
MAK, Tak W
University Health Network (Toronto) $153,480 MCC 5 Yr(s)
Princess Margaret Hospital (Toronto)
The roles of PTEN and PI3'K signalling components in tumorigenesis
MAK, Tak W
University Health Network (Toronto) ARPAIA, Enrico $148,998 MCC 5 Yr(s)
Influence of alterations to the cell's cytoskeleton on tumour cell metastasis.
MARTEL, Sylvain
École polytechnique de Montréal BEAUDOIN, Gilles / GABOURY, Louis / LEROUX, Jean- Christophe / SOULEZ, Gilles / YAHIA, L'Hocine
 $72,971 BME 3 Yr(s)
MRI Based Targeting of Therapeutic Magnetic Micro Carriers for Chemoembolization of Liver Tumors
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
9
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MCGLADE, Catherine J
Hospital for Sick Children (Toronto) $179,574 MCC 5 Yr(s)
Role of the SLAP adaptor proteins in ubiquitin dependent regulation of receptor tyrosine kinases.
MCWILLIAMS, Annette M
University of British Columbia LAM, Stephen / MACAULAY, Calum E
 $102,158 CBT 3 Yr(s)
BC Cancer Agency (Vancouver, BC)
Detection of Lung Cancer using an Electronic Nose
MILLER, Wilson H
Jewish General Hospital (Montreal) PETTERSSON, Filippa $138,305 CBT 5 Yr(s)
Lady Davis Institute for Medical Research (Mtl)
Novel mediators of response and resistance to epigenetic therapy of leukemia
MINCHINTON, Andrew I
University of British Columbia $127,686 CPT 4 Yr(s)
B.C. Cancer Research Centre (Vancouver)
Extravascular distribution of anticancer drugs
PETRIK, Jim J
University of Guelph MOOREHEAD, Roger A $92,536 CPT 3 Yr(s)
Thrombospondin-1 as an inibitor of epithelial ovarian cancer
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
10
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
POIRIER, Donald
Université Laval LIN, Sheng-Xiang $114,056 PS 4 Yr(s)
Centre hospitalier de l'Université Laval (Québec)
Inhibiteurs des isoformes 1, 3 et 12 de la 17beta-HSD à double action (sélectifs et sans activité résiduelles sur ER et AR) pour contrôler les niveaux d'estrogènes et d'androgènes dans les tumeurs cancéreuses du sein et de la prostate
POIRIER, Guy G
Université Laval HENDZEL, Michael J / MASSON, Jean-Yves
 $181,202 CBT 5 Yr(s)
Centre hospitalier de l'Université Laval (Québec)
Signalling functions of poly(ADP-ribosyl)ation in the DNA damage response and cancer.
PRAKASH, Satya
McGill University ALAOUI-JAMALI, Moulay A
 $121,100 CBT 3 Yr(s)
Development of a novel receptor targeted drug delivery system for metastatic breast cancers using polymeric membrane drug- functionalized carbon nanotubes.
RASSART, Eric
Université du Québec à Montréal $148,251 VVP 5 Yr(s)
Murine leukemia viruses : molecular characterization and search for oncogenes
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
11
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
RENNIE, Paul S
University of British Columbia CULLIS, Pieter R $150,500 E 3 Yr(s)
In vivo siRNA knockdown of androgen receptors to treat advanced prostate cancer
ROTIN, Daniela
Hospital for Sick Children (Toronto) $166,837 CBM 5 Yr(s)
Biological Functions of the Protein Tyrosine Phosphatase, PTPsigma
SANCHE, Léon
Université de Sherbrooke HUNTING, Darel J / WAGNER, James R
 $141,649 MPI 5 Yr(s)
Secondary electron collision cross sections for use in radiotherapy and radioprotection. Sections efficaces de diffusion des électrons secondaires pour utilisation en radiothérapie et radioprotection.
SCHMITT, Estelle M
Centre Hosp. de l'Université de Montréal (CHUM)
 $101,724 CBT 3 Yr(s)
Spatial coordination of DNA-damage response network: The centrosomal regulation of G2/M cell cycle checkpoint.
SCHRADER, John W
University of British Columbia $114,441 MCC 5 Yr(s)
Molecular characterization of the role of the elevated levels of M-Ras in cancer
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
12
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SIU, K. W. Michael
York University (Toronto, Ontario) COLGAN, Terence J / MACMILLAN, Christina M / RALHAN, Ranju / WITTERICK, Ian
 $126,764 CPT 3 Yr(s)
Discovery, Identification and Verification of Novel Biomarkers in Head and Neck Cancer
SOMERS, Gino R
Hospital for Sick Children (Toronto) ZIELENSKA, Maria $91,564 CPT 3 Yr(s)
Pediatric undifferentiated soft tissue sarcomas - a model for understanding the mechanisms underlying sarcoma development
SUNG, Lillian
Hospital for Sick Children (Toronto) ALLEN, Upton D / BEYENE, Joseph
 $145,526 CIA 4 Yr(s)
Predicting The Risk of Infection In Children Receiving Chemotherapy For Acute Myeloid Leukemia
TABORI, Uri
Hospital for Sick Children (Toronto) $128,604 CPT 3 Yr(s)
Prognostic and therapeutic implications for telomere maintenance and telomerase inhibition in pediatric high grade gliomas
TANGUAY, Robert M
Université Laval $120,400 EM 4 Yr(s)
Molecular analysis of the liver pathologies associated with tyrosinemia
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
13
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
TEODORO, Jose G
McGill University $116,478 VVP 5 Yr(s)
Role of the Anaphase Promoting Complex in Cancer and Viral Infection
TEODORO, Jose G
McGill University $134,915 CPT 3 Yr(s)
Characterization of novel mechanisms of angiogenesis inhibition
TRON, Victor A
Queen's University (Kingston, Ontario) ALLEN, Theresa M / ANDREW, Susan E
 $137,455 CPT 3 Yr(s)
Targeting anti-apoptotic Bcl-2 family members in malignant melanoma
VALLIERES, Luc
Université Laval $117,807 CBM 4 Yr(s)
Centre hospitalier de l'Université Laval (Québec)
Interactions between glioma cells and blood vessels
WANG, Yuzhuo
University of British Columbia GLEAVE, Martin E $129,000 CBT 3 Yr(s)
A novel molecular target for metastatic prostate cancer therapy
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
14
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
WASTENEYS, Geoffrey O
University of British Columbia $128,195 CBM 3 Yr(s)
Function and control of the Tumor Overexpressed Gene class of microtubule- associated proteins: Quantitative in vivo analysis of microtubule dynamics in a plant model.
WHYNE, Cari M
YEE, Albert J
FINKELSTEIN, Joel A $94,966 BME 4 Yr(s)
Sunnybrook Health Sciences Centre
Bone stability and tumor burden in the metastatic spine: Implications of variable disease patterns
WINOCUR, Gordon
Trent University (Peterborough, Ontario) HENKELMAN, R. Mark / TANNOCK, Ian F / WOJTOWICZ, Jan M
 $64,288 BSA 3 Yr(s)
An investigation of Effects of Chemotherapy on Cognitive Function in an Animal Model
WISMER, Wendy V
University of Alberta $53,150 PLC 3 Yr(s)
Alberta Cancer Board (Edmonton)
A multidimensional evaluation of chemosensory perception in the advanced cancer population
YOUSEF, George M
St. Michael's Hospital (Toronto) $99,441 CPT 3 Yr(s)
Differential Expression of microRNAs in Kidney Cancer and Their Potential Utility as Cancer Biomarkers
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
15
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Cancer Research / Cancer
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ZHENG, Gang
University Health Network (Toronto) BISLAND, Stuart K / WILSON, Brian C
 $150,500 CPT 3 Yr(s)
Ontario Cancer Institute (Toronto)
Protease-triggered photodynamic molecular beacons for cancer imaging and treatment
ZHU, Xu-Dong
McMaster University $126,265 CBT 5 Yr(s)
Functional Analysis of Proteins Involved in Telomere Length Maintenance
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
16
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
AHERN, Christopher A
University of British Columbia $131,817 CP 5 Yr(s)
Investigating anti-arrhythmic inhibition of voltage-gated sodium channels with unnatural amino acids and fluorescence spectroscopy.
AMREIN, Matthias W
University of Calgary SCHURCH, Friedrich S $113,033 RS 5 Yr(s)
Biophysical aspects of the interaction of airborne, ultrafine particles with the peripheral lung: Basic phenomena, health hazards and applications in drug delivery
ANAND-SRIVASTAVA, Madhu B
Université de Montréal $143,207 CSA 5 Yr(s)
Natriuretic petpide receptor C (NPR-C), signaling, regulation and cell fucntion
AUSTIN, Richard C
McMaster University $106,022 CSC 3 Yr(s)
Role of endoplasmic reticulum (ER) stress in the development and progression of atherothrombotic disease
BAI, Donglin
University of Western Ontario $107,143 CSA 5 Yr(s)
The role of connexin43 in cardiac function
BALLANYI, Klaus
University of Alberta $134,921 RS 5 Yr(s)
Chemosensitivity of the Isolated Inspiratory Center
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
17
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BERNATCHEZ, Pascal N
University of British Columbia $91,207 CSC 3 Yr(s)
St. Paul's Hospital, Vancouver
Increased eNOS activity and NO bioavailability through regulated eNOS- Caveolin-1 antagonism: new therapeutic avenues for vascular tone control
CLARKE, David M
University of Toronto $102,175 CBM 3 Yr(s)
The Molecular Mechanism of Rescue of CFTR Folding Defects Using Pharmacological Chaperones.
COLES, John G
Hospital for Sick Children (Toronto) $102,417 CSB 4 Yr(s)
Role of integrin-linked kinase (ILK) in Tetralogy of Fallot
DAVIS, Elaine C
McGill University $114,306 CSC 3 Yr(s)
Regulation of Vascular Wall Development
FLORAS, John S
University Health Network (Toronto) BRADLEY, Douglas T / KIMMERLY, Derek S
 $60,000 CSB 3 Yr(s)
Central Regulation of Autonomic Cardiovascular Function in Human Heart Failure and Obstructive Sleep Apnea
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
18
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
FOURNIER, Alain
INRS - (Québec, QC) $101,273 PT 5 Yr(s)
Molecular pharmacology of urotensin II, a cardiovascular peptide hormone.
GROSS, Gil J
Hospital for Sick Children (Toronto) REDINGTON, Andrew N $132,295 CSB 4 Yr(s)
Contractile adaptations to constrained heart rate conditions
GUILLEMETTE, Gaétan
Université de Sherbrooke $122,223 PT 5 Yr(s)
Régulation des récepteurs de l'inositol 1,4,5- trisphosphate par FKBP12 via ses effecteurs mTOR et calcineurine
HESS, David A
Robarts Research Institute - U.W.O. (London, Ont.)
 $118,016 CSC 3 Yr(s)
University of Western Ontario
Cellular constituents and paracrine pathways that mediate functional vascular regeneration.
KARMAZYN, Morris
University of Western Ontario $159,014 CSA 5 Yr(s)
Role of Leptin in Cardiac Hypertrophy and Heart Failure
KAVANAGH, Brian Patrick W
Hospital for Sick Children (Toronto) POST, Martin $138,454 RS 5 Yr(s)
Ventilator-Induced Lung Injury: Linking Gene Expression, Physiology and Outcome
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
19
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LEE, Douglas S
University Health Network (Toronto) ALTER, David A / AUSTIN, Peter C / LAUPACIS, Andreas / SCHULL, Michael J / STUKEL, Therese A / TU, Jack V / YOU, John J
 $144,730 HSI 3 Yr(s)
Institute for Clinical Evaluative Sciences- Toronto
Emergent Care and Outcomes of Acute Heart Failure
LESSARD, Julie
Université de Montréal $132,443 DEV 5 Yr(s)
Developmental Roles of Hemopoietic-Specific ATP-Dependent Chromatin Remodeling
LI, Ren-Ke
University Health Network (Toronto) $136,224 CSA 5 Yr(s)
An angiogenic progenitor cell niche in the uterus: potential implications for cell therapy
LIGHT, Peter E
University of Alberta $140,068 CSA 5 Yr(s)
Calcium homeostasis and metabolism in the diseased heart
MAGHNI, Karim
LEMIERE, Catherine WELMAN, Mélanie $104,680 RS 4 Yr(s)
MALO, Jean-Luc
Hôpital du Sacré-Coeur de Montréal
Role of Tac1 and Tac1R genes in basophil function: Implications for asthma
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
20
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MATHIEU, Patrick
PIBAROT, Philippe J
DESPRES, Jean-Pierre / LAROSE, Eric / PICARD, Frédéric
 $89,472 CSB 5 Yr(s)
Université Laval
Institut universitaire de cardiologie et pneumologie de Québec
Implication of atherosclerotic pathways and metabolic risk factors in the structural deterioration of bioprosthetic heart valves
MICHELAKIS, Evangelos D
University of Alberta $145,837 CSC 3 Yr(s)
The metabolic basis of vascular remodeling in pulmonary hypertension
MURRAY, Allan G
University of Alberta $117,043 CSC 3 Yr(s)
Lymphocyte-endothelial cell interactions in inflammation
OUDIT, Gavin Y
University of Alberta $123,453 CSB 5 Yr(s)
Role of Angiotensin Converting Enzyme 2 (ACE2) in Heart Disease: using human recombinant ACE2 as Potential Therapy
PETERS, Terence M
Robarts Research Institute - U.W.O. (London, Ont.)
 DRANGOVA, Maria / GUIRAUDON, Gerard M / JONES, Douglas L
 $116,913 MPI 5 Yr(s)
Image-guidance for minimally-invasive cardiac procedures
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
21
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
POST, Martin
KAVANAGH, Brian Patrick W
$123,795 RS 5 Yr(s)
MCKERLIE, Colin
PACE-ASCIAK, Cecil R
Hospital for Sick Children (Toronto)
Therapeutic potential of anti-inflammatory Hepoxilin analogs
PRAUD, Jean-Paul
Université de Sherbrooke $131,363 RS 5 Yr(s)
Laryngeal function and neonatal respiration
RATHBONE, Michel P
JIANG, Shucui
SALEH, Tarek M $124,919 CSB 2 Yr(s)
McMaster University
Neuroprotective properties of guanosine in experimental stroke
ROTIN, Daniela
Hospital for Sick Children (Toronto) $139,836 RS 5 Yr(s)
Role of Nedd4 proteins in lung function and development
SHRIER, Alvin
McGill University YOUNG, Jason C $123,035 CSA 5 Yr(s)
Mechanisms of hERG trafficking
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
22
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
STRACHAN, Patricia H
McMaster University ARTHUR, Heather M / CARROLL, Sandra L / SCHWARTZ, Lisa J
 $45,990 PSB 2 Yr(s)
Exploring patients' decisions regarding implantable defibrillators for primary prevention
STRAUSS, Bradley H
Sunnybrook Health Sciences Centre DICK, Alexander J / FOSTER, F. S / GOERTZ, David E / WRIGHT, Graham A
 $159,100 CSB 3 Yr(s)
Therapeutic Strategies for Chronic Total Occlusion Revascularization
TER KEURS, Hendrik E
University of Calgary $120,842 CSB 3 Yr(s)
Reduced Force of the Heartbeat in Congestive Heart Failure: Dysfunctional Ca2+ Transport
TESSON-RULKO, Frédérique
LEENEN, Frans H STEWART, Alexandre F $206,343 CSC 3 Yr(s)
University of Ottawa
University of Ottawa Heart Institute
Genetic basis of salt sensitive hypertension in humans.
TINMOUTH, Alan T
Ottawa Health Research Institute CALLUM, Jeannie L / FERGUSSON, Dean A / GRIMSHAW, Jeremy M / HEBERT, Paul C / MCINTYRE, Laura-Lyn A / RAMSAY, Timothy O / SHOJANIA, Kaveh G / WEBERT, Kathryn E
 $183,430 HSR 1 Yr(s)
6 Mths
Ottawa Hospital General Campus (Ottawa Ontario)
Appropriateness of Frozen Plasma Use in Canada
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
23
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Circulatory and Respiratory Health / Santé circulatoire et respiratoire
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
WADDELL, Thomas K
University Health Network (Toronto) $112,629 RS 5 Yr(s)
The role of bone marrow progenitors in lung regeneration
WANG, Rui
Lakehead University (Thunder Bay, Ontario) $133,527 CSB 5 Yr(s)
CSE deficiency-related hypertension development
WANG, Zhiguo
Montreal Heart Institute $164,682 CSA 4 Yr(s)
MicroRNAs and Electrical, Structural and Metabolic Remodeling in Atrial Fibrillation
WANG, Zhiguo
Montreal Heart Institute $138,761 CSB 3 Yr(s)
A Signature Pattern of Stress-Responsive microRNAs that Can Induce Cellular Injuries during Myocardial Infarction
WASAN, Kishor M
University of British Columbia LEON, Carlos G / SACHS-BARRABLE, Kristina / THORNTON, Sheila J
 $104,625 PS 3 Yr(s)
Physiological Role of P-Glycoprotein in Regulating the Gastrointestinal Absorption and Cellular Transport of Cholesterol
YANG, Decheng
University of British Columbia $99,975 CSB 4 Yr(s)
St. Paul's Hospital, Vancouver
Endoplasmic reticulum stress in coxsackievirus-induced myocarditis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
24
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Gender and Health / Santé des femmes et des hommes
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ALVAREZ, Fernando
Hôpital Sainte-Justine (Montréal) $111,483 GSH 4 Yr(s)
Influence of sex organs and hormones on autoimmune hepatitis development
MARTIN, Ruth E
JANSSEN, Patricia A BUCHANAN-ARVAY, Marla / BUXTON, Jane / CONDELLO, Lara-Lisa / CORNEIL, Trevor A / DESMARAIS, Sarah L / FAIRBROTHER, Nichole / FELS, Lynn M / FRANKISH, Charles J / GRANGER-BROWN, Alison J / LEGGO, Carl / MACAULAY, Ann C / OGILVIE, Gina S / RAMSDEN, Vivian R / SHANNON, Kate / WARDMAN, Dennis A
 $124,023 GSH 3 Yr(s)
University of British Columbia
Undetermined
Doing Time: A Time for Incarcerated Women to Develop an Action Health Strategy
SOON, Judith A
University of British Columbia HANLON, Neil T / JOHNSON, Joy L / KELM, Mary-Ellen / SHOVELLER, Jean A
 $90,867 GSH 2 Yr(s)
Experiences with contraception among youth in northern BC: Examining the impact of gender, place and culture
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
25
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
AMRE, Devendra
Hôpital Sainte-Justine (Montréal) DESLANDRES, Colette / LEVY, Emile / MACK, David R / SEIDMAN, Ernest G
 $140,168 PUB 3 Yr(s)
Investigation of genetic markers that determine susceptibility and clinical phenotypes of inflammatory bowel diseases
ATTISANO, Liliana
University of Toronto $157,381 MCC 5 Yr(s)
Signalling by serine/threonine kinase receptors
BOGGS, Joan M
Hospital for Sick Children (Toronto) HARAUZ, George $140,825 CP 5 Yr(s)
Functions of Myelin Basic Protein in Oligodendrocytes and Myelin
BOULIANNE, Gabrielle L
Hospital for Sick Children (Toronto) $159,628 DEV 5 Yr(s)
The role of presenilin in Notch signaling
COLAVITA, Antonio
Ottawa Health Research Institute $138,807 DEV 3 Yr(s)
Understanding the Role of Planar Cell Polarity Proteins in Establishing and/or Maintaining Neuronal Polarity in C. elegans
COLLINS, Richard A
University of Toronto $148,288 BMB 5 Yr(s)
Mechanism of catalysis and biological significance of the Neurospora VS ribozyme
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
26
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
DOSTIE, Josée
McGill University $151,751 GMX 5 Yr(s)
Role of Spatial Chromatin Organization in Genome Regulation
DUCHAINE, Thomas
McGill University $125,323 GMX 5 Yr(s)
RNAi-mediated genetic regulation loops
FUNNELL, Barbara E
University of Toronto $143,758 BMB 5 Yr(s)
Mechanisms of action of ParA and ParB proteins in bacterial plasmid segregation
GAGNON, France
University of Toronto WELLS, Philip S $138,275 G 4 Yr(s)
Search for modifier genes in familial thrombophilia with Factor V Leiden variant: A look at the hemostatic pathways
GLOVER, John R
University of Toronto $122,310 CP 3 Yr(s)
Structure, function, and biology of the chaperone Hsp104
GREWAL, Savraj S
University of Calgary $137,558 CBM 5 Yr(s)
The control of ribosome synthesis and cell growth by the target-of-rapamycin (TOR) pathway
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
27
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
HALLAM, Steven J
University of British Columbia $132,999 GMX 3 Yr(s)
Functional Metagenomic Investigation of Archaeal Serine Protease Inhibitors
HUI, Chi-Chung
Hospital for Sick Children (Toronto) $144,862 DEV 4 Yr(s)
Control of hindlimb development and patterning by the Iroquois homeobox genes
IGDOURA, Suleiman A
McMaster University $148,254 G 5 Yr(s)
Molecular mechanisms of pathogenesis for lysosomal storage diseases
JEANNOTTE, Lucie
Université Laval AUBIN, Josée $194,317 DEV 5 Yr(s)
Centre de recherche de L'Hôtel-Dieu de Québec
Analysis of Hoxa5 gene function in cell fate during mammalian organogenesis
KIBAR, Zoha
Hôpital Sainte-Justine (Montréal) $125,343 G 5 Yr(s)
Identification and characterization of genes predisposing to Neural Tube Defects in humans
KRAUSE, Henry M
University of Toronto $258,000 GMX 5 Yr(s)
Genome-wide analysis of mRNA subcellular trafficking
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
28
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LAM, Wan L
University of British Columbia LAM, Stephen / MACAULAY, Calum E / NG, Raymond
 $171,057 GMX 4 Yr(s)
B.C. Cancer Research Centre (Vancouver)
Integrative analysis of lung cancer genomes
LEGAULT, Pascale
Université de Montréal $135,794 BMA 3 Yr(s)
Structural and Engineering Studies of Ribozymes
LEVESQUE, Roger C
Université Laval $133,343 GMX 5 Yr(s)
Functional genomics and characterization of genes essential for in vivo maintenace in Pseudomonas aeruginosa
MASSON, Jean-Yves
Université Laval $141,212 MCC 5 Yr(s)
Centre de recherche de L'Hôtel-Dieu de Québec
Roles of homologous recombination proteins in DNA double-strand break repair and genome stability
MITCHELL, Grant A
Hôpital Sainte-Justine (Montréal) $129,333 G 4 Yr(s)
An Integrated Approach to Diseases of Coenzyme A Ester Metabolism
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
29
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MOFFAT, Jason
University of Toronto $156,015 GMX 5 Yr(s)
Functional identification of genes required for cellular adaptive evolution during nutrient/metabolic stress.
NAGANO, Makoto
The Research Institute of the McGill University Health Centre
 $133,026 E 5 Yr(s)
The regulatory mechanism of spermatogonial stem cell proliferation and differenitation
NISLOW, Corey E
University of Toronto HUGHES, Timothy R $158,802 GMX 4 Yr(s)
Genome-wide determinants of nucleosome occupancy and promoter definition
OSBORNE, Lucy R
University of Toronto MINASSIAN, Berge A $109,957 G 5 Yr(s)
Characterization of genetic and molecular mechanisms underlying infantile spasms, a common and catastrophic form of epilepsy in infants
PAI, Emil F
University Health Network (Toronto) $118,250 BMA 3 Yr(s)
Structural and Functional Analysis of Proteins Involved in Mg-homeostasis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
30
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ROCHELEAU, Christian E
McGill University $124,663 CBM 3 Yr(s)
Analysis of a putative Rab GTPase activating protein in endocytic trafficking
ROSE, Ann Marie
University of British Columbia HIETER, Philip A $125,388 BMB 5 Yr(s)
Genetic interactions with chromosome instability mutants in C. elegans to identify new anti-tumour targets
ROULEAU, Guy A
Centre Hosp. de l'Université de Montréal (CHUM)
 GASPAR, Claudia C $166,054 G 5 Yr(s)
Molecular Investigation of Expanded CAG Repeat Toxicity
ROUSSEAU, François
Université Laval BUREAU, Alexandre / COLE, David E / DODIN, Sylvie / LAFLAMME, Nathalie
 $150,869 G 2 Yr(s)
High density polymorphisms analysis of candidate genes involved in osteoporosis, bone remodeling and homeostasis.
RUDNER, Adam D
University of Ottawa $116,484 CP 5 Yr(s)
Control of the function and activity of the anaphase promoting complex by phosphorylation
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
31
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SCOTT, Ian C
Hospital for Sick Children (Toronto) $129,000 CSA 5 Yr(s)
Genetic and cellular analysis of the role of Agtrl1b in myocardial progenitor development.
SLIM, Rima
The Research Institute of the McGill University Health Centre
 QURESHI, Salman T / SALEH, Maya
 $117,793 G 3 Yr(s)
Elucidation of the molecular mechanisms responsible for hydatidiform moles
TRIGATTI, Bernardo L
McMaster University $132,169 CSC 3 Yr(s)
Role of SR-BI in the vascular wall in protection against occlusive coronary artery atherosclerosis and myocardial fibrosis in a unique mouse model.
VIDAL, Silvia M
The Research Institute of the McGill University Health Centre
 $132,268 G 5 Yr(s)
McGill University
Molecular genetics of host susceptibility to cardiovirulent coxsackievirus infection
VOGEL, Hans (Harm) J
University of Calgary $126,744 BMA 5 Yr(s)
Molecular characterization of two unique calcium-regulatory proteins involved in hemostasis and neuronal signaling
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
32
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Genetics / Génétique
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
WOODGETT, James (Jim) R
Mount Sinai Hospital (Toronto) NAGY, Andras $174,530 CBM 5 Yr(s)
Samuel Lunenfeld Research Institute (Toronto)
Signal transduction pathways controlling cell fate determination
ZETKA, Monique C
McGill University $108,471 G 5 Yr(s)
Dissection of pathways regulating meiotic chromosome segregation in C. elegans
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
33
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Health Services and Policy Research / Services et politiques de la santé
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
AUSTIN, Peter C
Sunnybrook Health Sciences Centre ANDERSON, Geoffrey M / TU, Jack V
 $49,661 HSI 3 Yr(s)
Institute for Clinical Evaluative Sciences- Toronto
Statistical methods for health services research
BREHAUT, Jamie C
Ottawa Health Research Institute FERGUSSON, Dean A / KIMMELMAN, Jonathan / SAGINUR, Raphael / SHOJANIA, Kaveh G
 $99,405 ELH 3 Yr(s)
Informing the decision to participate in a clinical trial: Can decision aids improve the quality of trial participation decisions?
BURGE, Frederick I
Dalhousie University (Nova Scotia) ARCHIBALD, Gregory C / CARR, Brendan S / GASS, David A / LAWSON, Beverley J / LUSSING, Frank J / MACPHAIL, Judith H / NATARAJAN, Nandini / PUTNAM, R. W
 $61,069 HSI 3 Yr(s)
Assessing the feasibility and acceptability of a quality outcome orientation to primary healthcare in Nova Scotia
DUMONT, Serge
JACOBS, Philip BURGE, Frederick I / CHOCHINOV, Harvey M / JOHNSTON, Grace M
 $97,370 HPM 3 Yr(s)
VILLENEUVE, Patrick
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Palliative care in Canada II: The economic perspective in rural areas
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
34
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Health Services and Policy Research / Services et politiques de la santé
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
FORTIN, Sylvie
Hôpital Sainte-Justine (Montréal) ALVAREZ, Fernando / BIBEAU, Gilles / CARNEVALE, Franco (Frank) A / DUVAL, Michel / GAUVIN, France
 $130,057 ELH 3 Yr(s)
Pratiques cliniques hospitalières et pluralisme urbain: L'arrimage d'une pédiatrie à la diversité de son milieu, PHASE II.
GAGLIARDI, Anna R
Sunnybrook Health Sciences Centre BROUWERS, Melissa C / GRIMSHAW, Jeremy M / LEMIEUX-CHARLES, Louise / MCLEOD, Robin S / PALDA, Valerie A
 $67,838 KTE 2 Yr(s)
Developing capacity for knowledge translation: Identifying factors that improve practice guideline implementation
GLAZIER, Richard H
St. Michael's Hospital (Toronto) BARNSLEY, Janet / GUTTMANN, Astrid / HOGG, William E / JAAKKIMAINEN, Ritva L / MANUEL, Douglas G / RHODES, Anne E / SCHULL, Michael J / STEELE, Leah S / STEWART, Moira A / STUKEL, Therese A / THIND, Amardeep / TU, Karen / UPSHUR, Ross E / ZWARENSTEIN, Merrick F
 $179,181 HSI 4 Yr(s)
Institute for Clinical Evaluative Sciences- Toronto
Examining the impact of primary care reform in Ontario on access to and quality of care
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
35
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Health Services and Policy Research / Services et politiques de la santé
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
GRACE, Sherry L
University Health Network (Toronto) ARTHUR, Heather M / PRIOR, Peter L / REID, Robert D / STEWART, Donna E / SUSKIN, Neville G
 $92,041 HSR 3 Yr(s)
Comparing paper versus electronic transmission of cardiac rehabilitation summaries to primary care physicians: A multi-site multi-method study of information flow and content
HEMMELGARN, Brenda R
University of Calgary AHMED, Sofia B / CROWSHOE, Lynden (Lindsay / FARIS, Peter D / GHALI, William A / MANNS, Braden J / TONELLI, Marcello A
 $79,421 ABH 2 Yr(s)
Progression and management of chronic kidney disease among First Nations People
LIPMAN, Ellen L
McMaster University MARZIALI, Elsa $87,943 HSI 1 Yr(s)
6 Mths
Web-based Mental Health Services for At-Risk Women: A Pilot Study
MIEDEMA, Baukje
Dalhousie University (Nova Scotia) LAMBERT-LANNING, Anita / LEMIRE, Francine L / MANCA, Donna P / RAMSDEN, Vivian R / TATEMICHI, Sue R
 $51,172 HPM 3 Yr(s)
Dr. Everett Chalmers Hospital (Fredericton)
Family Physicians and Workplace Abusive/Violent Encounters: Prevalence, Incidence, Impact and Strategy.
NEWBOLD, Kenneth B
McMaster University BIRCH, Stephen / EYLES, John D / WILSON, Kathleen J
 $62,083 HPM 3 Yr(s)
Journey to health: An investigation of the social production of health and access to care within hamilton's refugee community
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
36
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Health Services and Policy Research / Services et politiques de la santé
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
OREMUS, Mark
TARRIDE, Jean-Eric
RAINA, Parminder S $226,799 HPM 2 Yr(s)
McMaster University
An assessment of Canadians' willingness-to- pay for Alzheimer's disease medications: patients, caregivers, and the general public.
PADWAL, Raj S
KLARENBACH, Scott BIRCH, Daniel W / FASSBENDER, Konrad / MCCARGAR, Linda J
 $123,111 HSR 4 Yr(s)
MAJUMDAR, Sumit R
SHARMA, Arya M
University of Alberta
Royal Alexandra Hospital (Edmonton)
A Population-based, Prospective Controlled Evaluation of the Clinical, Economic and Humanistic Outcomes Associated with Bariatric Surgery
ROCHETTE, Annie
Université de Montréal JAMIESON, Isabelle / LEFEBVRE, Helene / RACINE, Eric
 $67,963 ELH 2 Yr(s)
Besoins des proches, implication dans les soins et services de santé et enjeux éthiques post- accident vasculaire cérébral (AVC) selon trois perspectives: proches, personnes ayant subi l'AVC et professionnels de la santé
ROSYCHUK, Rhonda J
University of Alberta KLASSEN, Terry P / ROWE, Brian H / SENTHILSELVAN, Ambikaipakan / VOAKLANDER, Donald C
 $83,173 HSR 1 Yr(s)
6 Mths
Respiratory presentations to Alberta emergency departments: Description and detection of clusters
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
37
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Health Services and Policy Research / Services et politiques de la santé
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SIMUNOVIC, Marko
BAXTER, Nancy N
CADEDDU, Margherita O / CHARLES, Cathy A / GUYATT, Gordon H / STRAUS, Sharon E / SUTRADHAR, Rinku / THABANE, Lehana / URBACH, David R
 $144,765 HSR 3 Yr(s)
McMaster University
Juravinski Cancer Centre (Hamilton, ON)
Assessing the uptake and effectiveness of laparoscopic surgery for colorectal cancer in Ontario
STIELL, Ian G
Ottawa Health Research Institute BREHAUT, Jamie C / DAVIES, Barbara L / GRIMSHAW, Jeremy M / O'CONNOR, Annette M / PERRY, Jeffrey J / WELLS, George A
 $78,677 HSR 2 Yr(s)
Evaluation of the Safety of C-Spine Clearance by Emergency Department Triage Nurses (Phase IV)
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
38
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ALAIN, Claude
Baycrest Centre for Geriatric Care (Toronto) ROSS, Bernhard / TREMBLAY, Kelly L
 $85,285 BSC 3 Yr(s)
Baycrest Hospital (North York)
Neural Mechanisms of Auditory-Based Remediation Programs
BERNARD, Daniel J
McGill University $140,928 E 5 Yr(s)
Bone morphogenetic protein signaling in gonadotrope cells
CANIGGIA, Isabella
Mount Sinai Hospital (Toronto) POST, Martin / ZAMUDIO, Stacy
 $157,498 E 5 Yr(s)
The role of oxygen in regulating placental development
CHAN, Peter T
McGill University HALES, Barbara F / ROBAIRE, Bernard
 $114,639 CIA 4 Yr(s)
Impact of cancer and chemotherapy on the nuclear proteins in spermatozoa.
CHEN, Xi-Kuan
University of Ottawa KREWSKI, Daniel R / SMITH, Graeme N / WALKER, Mark C / WEN, Shi Wu / YANG, Qiuying
 $45,905 CHI 2 Yr(s)
Beta blockers for the treatment of chronic hypertension and gestational hypertension and adverse perinatal outcomes
CHEUNG, Po-Yin
University of Alberta $160,605 CSB 4 Yr(s)
The cardiovascular support in newborns with hypoxia-reoxygenation injury
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
39
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
COTE, Jocelyn
University of Ottawa $152,427 CBM 5 Yr(s)
The role of the tudor domain in SMN axonal activities
CROSS, James C
University of Calgary $202,349 DEV 5 Yr(s)
Regulation of chorioallantoic morphogenesis
DANIEL, Sam J
The Research Institute of the McGill University Health Centre
 $99,491 CIA 3 Yr(s)
Montreal Children's Hospital
Prevention of cisplatinum ototoxicity
DEWEY, Deborah M
University of Calgary BARLOW, Karen M / BEAULIEU, Christian / BERNIER, Francois P / CANTELL, Marja C / CAUSGROVE DUNN, Janice L / GOODYEAR, Bradley G / KOOISTRA, Libbe / MARAJ, Brian K / MOHAMED, Ismail S / WELSH, Timothy N
 $227,173 CHI 5 Yr(s)
Developmental Motor Disorders: From Genes to Behaviour
FEHLINGS, Darcy L
Bloorview Kids Rehab (Toronto) GOLDSMITH, Charles H / NARAYANAN, Unni / ROSENBAUM, Peter L / WRIGHT, Virginia F
 $94,657 CHI 4 Yr(s)
6 Mths
An Evaluation of the Long-term Effectiveness of Botulinum Toxin in Children with Spastic Cerebral Palsy
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
40
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
GRUNAU, Ruth E
University of British Columbia BRANT, Rollin F / MILLER, Steven P / SYNNES, Anne R / WEINBERG, Joanne / WHITFIELD, Michael F
 $124,757 CHI 5 Yr(s)
Child and Family Research Institute
Stress and neurodevelopment in children born preterm
HALES, Barbara F
McGill University $160,340 PT 5 Yr(s)
Teratogen-induced signalling pathways during limb development
HARDY, Pierre
Hôpital Sainte-Justine (Montréal) $138,717 CIA 3 Yr(s)
Anti-Angiogenic Properties of Lymphocyte Microparticles: Innate Recognition and Regulation by Phosphatidylserine Receptor in Oxygen-Induced Retinopathy.
HEMMINGS, Denise G
University of Alberta $106,395 CIA 3 Yr(s)
Regulation of uterine and placental vascular responses to sphingosine 1-phosphate
KEIGHTLEY, Michelle
University of Toronto JOHNSTON, Karen M / LOBAUGH, Nancy J / PTITO, Alain
 $111,970 CHI 3 Yr(s)
An fMRI Study of the Neural and Clinical Implications of Pediatric Sports-Related Concussion
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
41
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
KELLY SPURLES, Patricia L
Mount Allison University (New Brunswick) DOYLE, Judith E $81,356 CHI 1 Yr(s)
Breastfeeding decisionmaking in low-initiation rate populations: A qualitative study of women's experience and decisionmaking regarding breastfeeding supplementation and cessation in New Brunswick and Nova Scotia
KIDDER, Gerald M
University of Western Ontario $158,215 DEV 5 Yr(s)
Roles of gap junctional coupling in oogenesis
KOSZYCKI, Diana
University of Ottawa BRADWEJN, Jacques / FLAMENT, Martine F / GOW, Robert M / KENNEDY, James L / MERALI, Zulfiquar / SCHNEIDER, Barry H / TALJAARD, Monica
 $128,403 CHI 5 Yr(s)
University of Ottawa Institute of Mental Health Research
Children at risk for panic disorder
LACHAPELLE, Pierre
CHEMTOB, Sylvain
SAPIEHA, Przemyslaw S / VARMA, Daya R
 $112,240 CIA 4 Yr(s)
The Research Institute of the McGill University Health Centre
Retinal distribution of structural and functional changes in retinopathy of prematurity: Involvement of choroid affected by nitrative stress mediators.
LEHMAN, Michael N
University of Western Ontario $123,464 CIA 4 Yr(s)
Prenatal programming of the reproductive neuroendocrine system
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
42
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LOISELLE, Marguerite
Direct Payment DUGRÉ, Suzanne / GRENIER, Stéphane / MARCEAU, Richard / POTVIN, Micheline
 $106,067 ABH 3 Yr(s)
Université du Québec en Abitibi- Témiscamingue
Le retour des jeunes enfants dans la communauté algonquine de Kitcisakik: une recherche action visant l'engagement de la commuanauté envers la santé et le bien-être des enfants.
MANJUNATH, Puttaswamy
Hôpital Maisonneuve-Rosemont (Montréal) $117,031 E 2 Yr(s)
6 Mths
Insights into the mechanisms underlying fertility: Role of novel phospholipid-binding proteins in sperm function
MCKEEVER, Patricia D
RUDDICK, Susan M
DOHERTY, Sean T / DUNN, James R / YANTZI, Nicole / YOUNG, Nancy L
 $120,256 CHI 3 Yr(s)
Bloorview Kids Rehab (Toronto)
School, Home and Neighbourhood Accessibility: Physically Disabled Children's Assessments (The ScHaN Project)
ROBAIRE, Bernard
McGill University $150,202 GSH 5 Yr(s)
Androgen action in the epididymis
RONEN, Gabriel M
McMaster University BOYLE, Michael H / CUNNINGHAM, Charles E / LACH, Lucyna M / ROSENBAUM, Peter L / STREINER, David L
 $153,497 PSD 5 Yr(s)
Outcome Trajectories in Children with Epilepsy: What Factors are Important?
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
43
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SMITH, Francine G
University of Calgary $135,949 CSB 5 Yr(s)
Blood volume regulation during ontogeny
STEVENS, Bonnie J
Hospital for Sick Children (Toronto) BARWICK, Melanie A / CAMPBELL, Fiona / CHAMBERS, Christine T / COHEN, Janice S / CUMMINGS, Greta / ESTABROOKS, Carole Anne / FINLEY, G. A / JOHNSTON, Celeste / KAVANAGH, Patricia M / LATIMER, Margot A / LEE, Shoo K / LEMAY, Sylvie / MCGRATH, Patrick J / RASHOTTE, Judith M / ROSMUS, Christina B / SAWATZKY-DICKSON, Doris / SCOTT, Shannon D / SIDANI, Souraya / STINSON, Jennifer N / STREMLER, Robyn L / SYNNES, Anne R / TADDIO, Anna / VILLENEUVE, Edith / WARNOCK, Fay F / WILLAN, Andrew R / YAMADA, Janet
 $344,988 KTE 4 Yr(s)
Translating Research on Pain in Children (TROPIC) Study
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
44
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Human Development, Child and Youth Health / Développement et santé des enfants et des adolescents
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
TAKETO, Teruko
The Research Institute of the McGill University Health Centre
 $133,364 GSH 3 Yr(s)
Failure in the second meiotic division in the mouse oocyte
THOMAS-STONELL, Nancy L
Bloorview Kids Rehab (Toronto) ODDSON, Bruce / ROSENBAUM, Peter L
 $92,063 CHI 3 Yr(s)
Focus on the Outcomes of Communication Under Six (the FOCUS): Evaluating Validity and Responsiveness to Change
WEKSBERG, Rosanna
Hospital for Sick Children (Toronto) CHITAYAT, David A / KEATING, Sarah J / KINGDOM, John C
 $127,961 CIA 3 Yr(s)
Investigation of Intrauterine Growth Restriction by Gene Expression and DNA Methylation Profiling
WEN, Shi Wu
Ottawa Health Research Institute DAVIDGE, Sandra T / HONGZHUAN, Tan / SMITH, Graeme N / TRASLER, Jacquetta M / WALKER, Mark C / YANG, Qiuying
 $194,428 POP 5 Yr(s)
A pre-conception cohort to study preeclampsia: etiology, early biomarkers, and cardiovascular risk after childbirth.
WINN, Louise M
Queen's University (Kingston, Ontario) $107,539 PS 3 Yr(s)
Mechanisms of valproic acid induced teratogenesis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
45
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ALLEN, Upton D
BEYENE, Joseph
GRUNEBAUM, Eyal / MAZZULLI, Tony / READ, Stanley E / ROBINSON, Joan L / TELLIER, Raymond / WEITZMAN, Sheila S / ZIELENSKA, Maria
 $99,742 VVP 4 Yr(s)
Hospital for Sick Children (Toronto)
Epstein-Barr Virus in Health and Disease in Children and Youth: A Prospective Study of Markers of Virus-Host Interaction and Genetic Variation.
BALDWIN, Troy A
University of Alberta $134,677 IT 5 Yr(s)
Molecular examination of thymocyte negative selection in vivo
BEHR, Marcel A
The Research Institute of the McGill University Health Centre
 $118,202 MI 3 Yr(s)
NOD2 and mycobacterial infection
BOIVIN, Guy
Université Laval LIN, Sheng-Xiang $145,426 VVP 5 Yr(s)
Antiviral drug resistance in herpesviruses
BORASTON, Alisdair B
University of Victoria (British Columbia) VOCADLO, David $202,702 BMA 5 Yr(s)
Degradation of host glycans in the lung by Streptococcus pneumoniae.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
46
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BREMNER, Rod
University Health Network (Toronto) $180,050 G 5 Yr(s)
Toronto Western Research Institute (Toronto)
A Genome Wide siRNA Screen for Novel IFNgamma signaling components
BURROWS, Lori L
McMaster University $128,155 MI 5 Yr(s)
Pseudomonas aeruginosa type IV pilins
CARAYANNIOTIS, George
Memorial University of Newfoundland $126,786 IT 5 Yr(s)
Immunoregulation of experimental autoimmune thyroiditis
COULTON, James W
McGill University $160,497 BMA 5 Yr(s)
Structural biology of the bacterial TonB interactome
COWEN, Leah E
University of Toronto $109,263 MI 5 Yr(s)
Role of the Molecular Chaperone Hsp90 in Fungal Evolution, Drug Resistance, and Infectious Disease
DUONG, Frank
University of British Columbia $126,143 BMA 5 Yr(s)
Molecular dynamics of protein translocation through the bacterial membrane
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
47
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
EPAND, Richard M
McMaster University $82,044 MI 5 Yr(s)
Microbial Membranes and the Action of Antimicrobial Agents
FOWKE, Keith R
University of Manitoba $110,682 VVP 3 Yr(s)
Assessment of the functional mechanisms driving immune quiescence and infection resilience observed in HIV resistant sex workers.
GORDON, John R
University of Saskatchewan $134,934 IT 5 Yr(s)
Mechanisms mediating the therapeutic effects of tolerogenic dendritic cells
GOSSELIN, Jean
Université Laval $115,909 PT 3 Yr(s)
Centre Hospitalier Universitaire de Québec
Characterization of the physiological action of leukotriene B4 on the innate defense against viral infection
HAERYFAR, S.M. Mansour
University of Western Ontario $126,013 IT 5 Yr(s)
Regulation of antiviral cytotoxic T lymphocyte responses by innate invariant natural killer T cells
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
48
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
HANCOCK, Robert Ernest W
University of British Columbia HAMILL, Pamela C $109,107 MI 5 Yr(s)
Design and Function of Antimicrobial Peptides
HARDER, Kenneth W
University of British Columbia $136,164 IT 5 Yr(s)
Signaling thresholds controlling dendritic cell, monocyte, macrophage development and the innate immune response
HISCOTT, John
LIN, Rongtuan
$176,816 VVP 5 Yr(s)
Jewish General Hospital (Montreal)
Molecular Interactions regulating RIG-I signaling to the Innate Antiviral Response
HOBMAN, Tom C
University of Alberta $126,039 VVP 5 Yr(s)
Analyses of togavirus capsid protein functions in virus replication
JEFFERIES, Wilfred A
University of British Columbia $141,771 IT 5 Yr(s)
Studies on Antigen Presentation in Dendritic Cells
JONES, Nicola L
Hospital for Sick Children (Toronto) $103,575 EM 5 Yr(s)
Role of autophagy during H. pylori infection and disease
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
49
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LAMARRE, Daniel
Université de Montréal $128,656 VVP 3 Yr(s)
Discovery of HCV therapeutic targets using energy transfer technology.
LIU, Lixin
University of Saskatchewan $107,647 CSC 3 Yr(s)
LSP1 signaling mechanisms in chemokine- induced neutrophil emigration
LU, Rui (Ray)
University of Guelph $113,195 VVP 5 Yr(s)
Biological function(s) of Luman in human cellular processes and its potential role in herpesvirus infection
MAK, Tak W
University Health Network (Toronto) HAO, Zhenyue $131,795 IT 5 Yr(s)
Mechanisms of Cell Survival and Apoptosis in Immune System Cells
MAKRIGIANNIS, Andrew P
Institut de recherches cliniques de Montréal CARLYLE, James R $132,586 IT 5 Yr(s)
Genetic investigation of MHC-independent missing-self recognition by natural killer cells
MATSUUCHI, Linda
University of British Columbia $124,012 IT 5 Yr(s)
Signaling by the antigen receptor on B lymphocytes (BCR)
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
50
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MCISAAC, Warren J
Mount Sinai Hospital (Toronto) MAZZULLI, Tony / MOINEDDIN, Rahim
 $73,431 MI 3 Yr(s)
A National Study Of Community-Acquired Antibiotic Resistant E.Coli Causing Uncomplicated Urinary Tract Infections In Adult Women
MOHN, William W
University of British Columbia AV-GAY, Yossef $108,585 MI 5 Yr(s)
Mycobacterial cholesterol metabolism: A key piece in the pathogenesis puzzle?
MONEY, Deborah M
University of British Columbia BITNUN, Sean A / COTE, Hélène / COUTLÉE, François / DOBSON, Simon R / FORBES, John C / KLEIN, Marina B / KOLLMANN, Tobias R / KRAJDEN, Mel / LOUTFY, Mona R / OGILVIE, Gina S / PETRIC, Martin / PICK, Neora / RABOUD, Janet M / RACHLIS, Anita R / SMAILL, Fiona M / STUART, Gavin C / VAN SCHALKWYK, Julianne E / WALMSLEY, Sharon L / WOBESER, Wendy L
 $277,809 PUB 5 Yr(s)
Children's & Women's Health Centre of British Columbia
A Study of an HPV VLP Vaccine in a Cohort of HIV Positive Girls and Women
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
51
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MOROY, Tarik
Institut de recherches cliniques de Montréal $116,719 BMB 3 Yr(s)
The role of alternative splicing in the regulation of T-cell function
NAVARRE, William W
University of Toronto $118,306 MI 5 Yr(s)
The role of H-NS and related molecules in regulating bacterial virulence gene expression
PATEL, Kamala D
University of Calgary $135,042 RS 5 Yr(s)
Mechanotransduction in Leukocyte Trafficking
PELCHAT, Martin
University of Ottawa $89,569 VVP 5 Yr(s)
Mechanism of recognition of the hepatitis delta virus RNA promoters by the human RNA- polymerase II
RAMANATHAN, Sheela
Université de Sherbrooke $100,742 IT 5 Yr(s)
Regulation of apoptotic cell death in T lymphocytes by GIMAP5
ROUILLER, Isabelle
McGill University $110,901 BMA 5 Yr(s)
Structural and functional analyses of the mechanisms of protein penetration through membranes.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
52
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SCHRADER, John W
University of British Columbia PAI, Emil F $93,138 IT 5 Yr(s)
Structural investigations into the innate foundations of human antibody responses to vulnerable sites on common pathogens
SHI, Yan
University of Calgary $65,231 IT 3 Yr(s)
Purine in Immune Regulation
UZONNA, Jude E
University of Manitoba $140,175 MI 3 Yr(s)
Development, maintenance and loss of established anti-Leishmania immunity.
VAN DEN HURK (D.LITTEL), Sylvia
University of Saskatchewan $155,126 VVP 4 Yr(s)
Role of dendritic cells in virus-induced inflammation and antigen presentation in airway tissues.
WEIJER, Charles E
University of Western Ontario $77,731 ELH 4 Yr(s)
Conceptual Problems in Research Ethics IV
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
53
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Infection and Immunity / Maladies infectieuses et immunitaires
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
WYLIE, John L
JOLLY, Ann M
BEAUDOIN, Carole M / DAWOOD, Magdy R / VAN CAESEELE, Paul G
 $107,678 PSD 5 Yr(s)
University of Manitoba
The behavioural, social and cultural factors affecting the epidemiology of sexually transmitted and bloodborne pathogens in high- risk populations: Determining risk space in Canada's vulnerable populations
XING, Zhou
McMaster University $115,525 RS 5 Yr(s)
Regulation of type 1 immunity by immunoreceptor DAP12 in pulmonary mycobacterial infection
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
54
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ALMAN, Benjamin A
Hospital for Sick Children (Toronto) $186,335 CIB 5 Yr(s)
Molecular mechanisms in Fracture and Wound healing
ASMUNDSON, Gordon J
University of Regina (Saskatchewan) TAYLOR, Steven $81,454 PSD 3 Yr(s)
Understanding the co-occurence of PTSD and chronic musculoskeletal pain: Do traumatic experiences alter perception and processing of pain stumuli?
BEIER, Frank
University of Western Ontario $121,058 CIB 3 Yr(s)
Transforming growth factor alpha in a rodent model of osteoarthritis
BEIER, Frank
University of Western Ontario $123,371 DS 5 Yr(s)
Rac1 function in endochondral ossification
BOILEAU, Christelle
Centre Hosp. de l'Université de Montréal (CHUM)
 MARTEL-PELLETIER, Johanne
 $106,410 CIB 4 Yr(s)
Étude de l'expression et de la régulation des récepteurs activés par les protéases (PARs) dans les tissus articulaires et mise en évidence des conséquences physiopathologiques de leur activation
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
55
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BOYD, Steven K
University of Calgary $87,201 BME 4 Yr(s)
Pre-clinical longitudinal assessment of bone health
BROMME, Dieter
University of British Columbia BRAYER, Gary D / DAVIES, Julian E
 $140,054 PS 3 Yr(s)
Isolation and characterization of potent and therapeutically relevant cathepsin K and S inhibitors from microbial product libraries
DUBOIS, Claire M
Université de Sherbrooke $122,015 CBM 4 Yr(s)
Characterization of tumor-like invadopodia in arthritic synovial cells
ELLEN, Richard P
University of Toronto $144,183 DS 5 Yr(s)
Signaling pathways for actin and chemotaxis perturbation in neutrophils by Treponema denticola
ELLIOTT, Janet A
MCGANN, Locksley E THOMPSON, Richard B $90,579 BME 4 Yr(s)
University of Alberta
Thermodynamics in Cryobiology and Applications in Biopreservation
FRANK, Cyril B
University of Calgary HART, David A / RONSKY, Janet L / SHRIVE, Nigel G
 $135,751 BME 5 Yr(s)
Ligament Transplantation
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
56
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
GHAHARY, Aziz
University of British Columbia ONG, Christopher J / ULUDAG, Hasan
 $157,422 CIB 5 Yr(s)
Development and Application of Non- Rejectable Allogenic Skin Substitute as a Wound Coverage
GIANGREGORIO, Lora Marie
University of Waterloo (Ontario) ADACHI, Jonathan D / MCCARTNEY, Neil / PAPAIOANNOU, Alexandra / POPOVIC, Milos R / THABANE, Lehana
 $85,477 PUB 3 Yr(s)
6 Mths
McMaster University
Bone quality in individuals with chronic spinal cord injury
GOLTZMAN, David
McGill University $139,860 CIB 4 Yr(s)
Hormonal regulation of skeletal and mineral homeostasis
GORNITSKY, Mervyn
BARON, Murray DAGENAIS, Marie / HUDSON, Marie / STEELE, Russell J
 $114,387 DS 2 Yr(s)
Jewish General Hospital (Montreal)
The impact of orofacial manifestations of systemic sclerosis on health-related quality of life
HANLY, John G
Dalhousie University (Nova Scotia) CLARKE, Ann E / FAREWELL, Vernon T / FORTIN, Paul R / GLADMAN, Dafna D / UROWITZ, Murray B
 $162,734 CIB 5 Yr(s)
An international, multi-center, prospective, inception cohort study of neuropsychiatric systemic lupus erythematosus (NP-SLE)
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
57
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
HENDY, Geoffrey N
The Research Institute of the McGill University Health Centre
 $140,964 M 5 Yr(s)
McGill University
Extracellular calcium-sensing receptor: studies of gene expression and regulation
HERZOG, Walter
University of Calgary $102,183 MOV 3 Yr(s)
Mechanical properties of sarcomeres and mechanisms of contraction
KANDEL, Rita A
Mount Sinai Hospital (Toronto) MASSICOTTE, Eric M / SANTERRE, Paul
 $152,179 BME 3 Yr(s)
Study of annulus fibrosus cells on polyurethane scaffolds and the regulation of matrix orientation: Towards tissue engineering a functional intervertebral disc
KNAUS, Edward E
University of Alberta $148,609 PS 3 Yr(s)
The design and evaluation of non-ulcerogenic COX-2 and/or 5-LOX antiarthritic agents and nitric oxide donor prodrug derivatives thereof.
KOEHOORN, Mieke W
University of British Columbia BARER, Morris L / CHHOKAR, Rahul S / COTE, Pierre / HOGG- JOHNSON, Sheilah / MCGRAIL, Kimberlyn M / MCLEOD, Christopher B
 $113,088 HSI 3 Yr(s)
Musculoskeletal surgeries among injured workers: Investigation of outcomes by surgical setting and expedited status
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
58
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
KOTHARY, Rashmi K
Ottawa Health Research Institute $146,114 CBM 5 Yr(s)
Understanding the pathophysiology of spinal muscular atrophy
LABELLE, Hubert B
Hôpital Sainte-Justine (Montréal) BEAUSEJOUR, Marie / FELDMAN, Debbie / FORTIER, Isabel / GOULET, Francois / GOULET, Lise / GRIMARD, Guy / PARENT, Stefan / ROSSIGNOL, Michel
 $74,937 HSR 3 Yr(s)
Plan d'organisation des services pour la prise en charge appropriée des patients avec scoliose suspectée.
OXLAND, Thomas R
University of British Columbia KOZLOWSKI, Piotr / KWON, Brian K / TETZLAFF, Wolfram G
 $155,060 BME 5 Yr(s)
Vancouver Coastal Health Research Institute
Clinically relevant mechanisms of spinal cord injury
POULIOT, Roxane
Université Laval POUBELLE, Patrice- Édouard
 $94,550 CIB 3 Yr(s)
Hôpital du Saint-Sacrement (Québec)
Comprendre la différenciation cellulaire accélérée des kératinocytes psoriasiques grâce au génie tissulaire
RAINVILLE, Pierre
MARCHAND, Serge
GOFFAUX, Philippe / PICHE, Mathieu / POTVIN, Stéphane
 $134,375 BSC 5 Yr(s)
Institut universitaire de gériatrie de Montréal
Electrophysiology and brain imaging of normal and abnormal pain modulatory systems
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
59
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ROTTAPEL, Robert K
University Health Network (Toronto) $134,561 CIB 3 Yr(s)
Ontario Cancer Institute (Toronto)
The adapter protein SH3BP2, encoded by the Cherubism Locus, regulates both OSTEOclast and OSTEOblast function
SARRET, Philippe
Université de Sherbrooke MELIK PARSADANIANTZ, Stéphane T
 $102,511 PT 3 Yr(s)
Les chimiokines : Nouvelles cibles thérapeutiques dans le traitement de la douleur.
TIRONA, Rommel G
University of Western Ontario KIM, Richard B $105,570 PS 3 Yr(s)
Role of Skeletal Muscle Transporters in Statin- Induced Myopathy
ULUDAG, Hasan
University of Alberta DOSCHAK, Michael R / GHAHARY, Aziz
 $136,634 BME 4 Yr(s)
Designing Amphiphilic Polymeric Carriers of DNA for Gene Therapy
VACHER, Jean
Institut de recherches cliniques de Montréal $138,630 CIB 2 Yr(s)
Molecular Analysis of Osteopetrosis
WUNDER, Jay S
Mount Sinai Hospital (Toronto) ALMAN, Benjamin A $161,589 CBM 5 Yr(s)
Hedgehog signaling in cartilage neoplasia and development
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
60
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Musculoskeletal Health and Arthritis / Appareil locomoteur et arthrite
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
YEUNG, Rae S
Hospital for Sick Children (Toronto) $141,738 CIB 3 Yr(s)
Kawasaki Disease: On our way to unraveling the pathogenesis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
61
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
AVOLI, Massimo
McGill University $78,685 NSA 5 Yr(s)
Montreal Neurological Institute
GABAA receptor function and epileptiform hyperexcitability in the fmr1 KO mouse subuculum: an approach to understanding fragile X syndrome
BAINS, Jaideep S
University of Calgary $153,321 NSA 5 Yr(s)
Stress induced plasticity of synaptic inhibition.
BAKER, Glen B
University of Alberta TODD, Kathryn G $144,782 PS 5 Yr(s)
Phenylalkylhydrazine drugs and neuroprotection.
BEN AMOR, Leila
Université Laval BARDEN, Nicholas / CHANTAL, Sophie / DESMARAIS, Paul- André / MORASSE, Karine / OUELLET- MORIN, Isabelle
 $100,448 BSB 3 Yr(s)
Hôtel-Dieu de Lévis (Lévis, Québec)
Imagerie génétique et Trouble Déficit de l'Attention/Hyperactivité (TDAH) chez les enfants franco-canadiens
BOHBOT, Véronique
Douglas Hospital Research Centre (Verdun, Québec)
 RAJAH, Maria N $64,173 BCA 2 Yr(s)
Virtual navigation and aging: bringing new perspectives on cognitive function in elderly
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
62
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BOUCHARD, Jean-Francois
Université de Montréal $114,480 PT 3 Yr(s)
Influence of cannabinoids on synaptogenesis and plasticity
BROWN, Arthur
University of Western Ontario $156,491 CBM 5 Yr(s)
Targeting SOX9 to alter scar gene expression and promote regeneration after spinal cord injury
BROWN, Thomas G
Douglas Hospital Research Centre (Verdun, Québec)
 DONGIER, Maurice H / LEPAGE, Martin / NADEAU, Louise / NG YING KIN, Ng Mien Kwong / OUIMET, Marie Claude / PRUESSNER, Jens C / TREMBLAY, Jacques
 $86,559 GSH 5 Yr(s)
Gender differences in the multidimensional assessment of DWI recidivism risk
CAO, Xudong
University of Ottawa GRIFFITH, May C / TSAI, Eve C
 $138,649 BME 3 Yr(s)
Bioengineering strategies to restore motor function after spinal cord injuries
CARBONETTO, Salvatore T
The Research Institute of the McGill University Health Centre
 RAO, Yong $97,627 NSB 3 Yr(s)
Dystroglycan regulates cell polarity and survival in the CNS
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
63
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
CARTER, Jacqueline C
University Health Network (Toronto) CROSBY, Ross / OLMSTED, Marion P / WOODSIDE, D. B
 $46,441 PSD 3 Yr(s)
A longitudinal study of relapse and recovery in anorexia nervosa
CHAHINE, Mohamed
Université Laval $129,325 CP 5 Yr(s)
Centre de recherche Université Laval-Robert- Giffard (QC)
Modulation of Nav1.7 and Nav1.8 peripheral nerve Na channels by Kinases, local anaesthetics and auxiliary beta-subunits
CHAUDHURI, Avi
McGill University $130,580 BSC 5 Yr(s)
The development of complex vision in primates
CHEN, Hsiao-Huei
Ottawa Health Research Institute $123,063 NSB 5 Yr(s)
Control of sensory neuron development
CHEN, Robert
University Health Network (Toronto) DASKALAKIS, Zafiris J / KENNEDY, James L / WONG, Albert H
 $184,040 MOV 5 Yr(s)
Toronto Western Research Institute (Toronto)
Mechanisms of cortical inhibition, facilitation and plasticity in humans
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
64
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
CHENG, Hai-Ying M
University of Ottawa $91,409 BSA 5 Yr(s)
Signal Transduction Mechanisms Underlying Circadian Timekeeping in Mammals
DELANEY, Kerry R
University of Victoria (British Columbia) $129,829 NSB 5 Yr(s)
Cellular and Network Analysis of Olfactory Bulb
DOYON, Julien
Institut universitaire de gériatrie de Montréal BENALI, Habib / BOULANGER, Yvan / HOGE, Richard D / LEHERICY, Stéphane / MAQUET, Pierre A / PEIGNEUX, Philippe
 $109,654 BSC 5 Yr(s)
Université de Montréal
Physiological mechanisms associated with the creation, consolidation and reconsolidation of a motor memory trace examined through functional brain imaging
DREW, Trevor B
Université de Montréal STAPLEY, Paul J $188,371 MOV 5 Yr(s)
Brainstem control of movement and posture in the cat
DURHAM, Heather D
McGill University GENTIL, Benoit J / HANCOCK, Mark A
 $131,010 NSA 4 Yr(s)
The Role of Protein Chaperones in Regulating Neurofilament Dynamics in Peripheral Sensorimotor Neuropathies
EVANS, Alan C
McGill University $148,178 BSC 5 Yr(s)
3-D Morphometry of Human Cortex
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
65
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
FERGUSON, Stephen S
University of Western Ontario $151,103 PT 4 Yr(s)
Regulation of CRF1/5HT2 Receptor Signalling Complexes
FRANKLAND, Paul W
Hospital for Sick Children (Toronto) $130,161 BSA 5 Yr(s)
Adult neurogenesis and hippocampal memory formation
GAUDET, Daniel
PAUS, Tomas
ABRAHAMOWICZ, Michal M / LABERGE, Luc / LEONARD, Gabriel / PAUSOVA, Zdenka V / PERRON, Michel / PIKE, G. Bruce / RICHER, Louis / SEGUIN, Jean R
 $272,095 CHI 5 Yr(s)
Université de Montréal
Hôpital de Chicoutimi (Québec)
Long-term consequences of prenatal exposure to maternal cigarette smoking on brain structure, function and mental health in adolescence: role of genes and environment in brain development
GEORGE, Susan R
O'DOWD, Brian F $140,567 BSA 5 Yr(s)
University of Toronto
Regulation of GPCR signaling complexes mediating opioid action
GOSGNACH, Simon
University of Alberta $100,057 MOV 3 Yr(s)
Analysis of the role of genetically-defined interneurons in the operation of the locomotor CPG.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
66
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
GOTMAN, Jean
McGill University DUBEAU, François / PIKE, G. Bruce
 $152,350 MPI 5 Yr(s)
Montreal Neurological Institute
Electrical and metabolic analysis of human epileptogenic lesions
GREEN, Robin E
MIKULIS, David J BAYLEY, Mark T / CHRISTENSEN, Bruce K / HEBERT, Deborah A / INNESS, Elizabeth L / MCILROY, William E / MONETTE, Georges
 $129,410 BSB 3 Yr(s)
Toronto Rehab Institute
Cognitive and Motor recovery following traumatic brain injury: Investigations of novel mechanisms and outcome predictors - Phase 2
HAYDEN, Elizabeth P
University of Western Ontario CHEN, Xinyin / HILL, Kathleen A / SINGH, Shiva M
 $156,874 BSB 5 Yr(s)
Gene-environment interplay and the developmental psychopathology of internalizing disorders
HO, Anthony K
University of Alberta $158,781 E 5 Yr(s)
The role of histone modifications in adrenergic-stimulated gene expression in the rat pineal gland
HOLROYD, Clay B
University of Victoria (British Columbia) KERNS, Kimberly A / MUELLER, Ulrich
 $73,000 BSB 5 Yr(s)
Neural mechanisms of reward learning and cognitive control in children with ADHD
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
67
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
JOHNSRUDE, Ingrid S
Queen's University (Kingston, Ontario) $95,853 BSC 5 Yr(s)
From sound to meaning: The neural and functional bases of speech perception.
JOSSELYN, Sheena A
Hospital for Sick Children (Toronto) $132,195 BSA 5 Yr(s)
The role of the transcription factor CREB in mammalian memory
KOEBERLE, Paulo D
University of Toronto $85,739 CIA 3 Yr(s)
The Role of Extracellular Matrix Interactions in Adult CNS Neuroprotection
KONTOS, Pia C
Toronto Rehab Institute COLANTONIO, Angela / COTT, Cheryl A / GILBERT, Julie E / KEIGHTLEY, Michelle / MITCHELL, Gail J
 $115,200 KTE 3 Yr(s)
After the Crash: Exploring knowledge translation through research-based drama
LE MELLEDO, Jean-Michel
University of Alberta ALLEN, Peter S / BAKER, Glen B / HANSTOCK, Christopher C / NEWMAN, Stephen C
 $152,553 GSH 3 Yr(s)
Assessment of brain neurochemical alterations with postpartum depression (PPD)
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
68
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
LECOMTE, Tania
GOLDNER, Elliot M
BRINK, Johann H / HONER, William G / KANG, G. Shimi K / LANG, Donna J / MACEWAN, William G / MUESER, Kim T / THORNTON, Allen E
 $68,818 PSB 2 Yr(s)
Université de Montréal
Simon Fraser University (Burnaby, B.C.)
The methamphetamine and psychosis study (MAPS)
LEYTON, Marco
McGill University BENKELFAT, Chawki / DAGHER, Alain
 $189,709 BSB 5 Yr(s)
Neurobiology of Cocaine Addiction: Striatal and Extra-Striatal Dopamine Release in Response to Relapse Precipitants
MARCHAND, André
Université du Québec à Montréal BELANGER, Claude / BOUCHARD, Stephane / DUGAS, Michel J / GOSSELIN, Patrick / LABRECQUE, Joane / LANGLOIS, Frederic
 $74,585 BSB 5 Yr(s)
Centre de recherche Fernand-Seguin de l'Hôpital Louis H.- Lafontaine (Mtl)
The Effect of a Combined versus a Conventional Cognitive-Behavioral Treatment for Comorbid Generalized Anxiety Disorder and Panic Disorder with Agoraphobia
MATHESON, Kimberly
ANISMAN, Hymie FOSTER, Mindi D $140,566 PSB 5 Yr(s)
Carleton University (Ottawa)
The cumulative impacts of everyday discrimination: Altered neuroendocrine and cytokine functioning and vulnerability to stress-related psychopathology.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
69
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
MCKINNEY, Rebecca A
McGill University $146,076 NSB 3 Yr(s)
The functions of dendritic spine shape and motility in the hippocampus
MCPHERSON, Peter S
McGill University $90,336 CBM 5 Yr(s)
Montreal Neurological Institute
Intracellular membrane trafficking in health and disease
MEANEY, Michael J
Douglas Hospital Research Centre (Verdun, Québec)
 $125,662 BSA 5 Yr(s)
The neurobiology of individual differences in maternal behaviour in the rat
MOUGINOT, Didier M
Université Laval $95,683 NSA 5 Yr(s)
Centre hospitalier de l'Université Laval (Québec)
Hypothalamic sodium sensor in salt appetite and osmoregulation
MULLIGAN, Sean J
University of Saskatchewan $76,699 NSB 3 Yr(s)
Bidirectional Communication Between Astrocytes and the Cerebrovasculature
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
70
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
NGUYEN, Peter V
University of Alberta $109,757 NSB 5 Yr(s)
Modulation of Synaptic Plasticity and Memory by Beta-Adrenergic Receptors
ORLOWSKI, John
McGill University $169,223 CP 5 Yr(s)
Function and Regulation of Neural Sodium/Proton Exchangers
ORSER, Beverley A
University of Toronto $165,261 NSA 5 Yr(s)
Tonic GABAergic regulation of memory and plasticity
PERETZ, Isabelle S
Université de Montréal $118,949 BSC 5 Yr(s)
Amusia: from behavior to brain, genes and plasticity
PETRIDES, Michael
McGill University $140,419 BSC 5 Yr(s)
Montreal Neurological Institute
Comparative study of the human and monkey cortex
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
71
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
RAHME, Elham
The Research Institute of the McGill University Health Centre
 BERNATSKY, Sasha R / BERRY, Gregory K / DASGUPTA, Kaberi / KAHN, Susan R
 $90,636 POP 3 Yr(s)
Risk-benefit ratio of extended thromboprophylaxis to prevent venous thromboembolism among patients undergoing hip or knee replacement surgery: An administrative database validity study
ROSE, Kenneth P
Queen's University (Kingston, Ontario) $171,090 MOV 5 Yr(s)
Input-output properties of neck motoneurons: The role of dendritic structure
ROULEAU, Guy A
Centre Hosp. de l'Université de Montréal (CHUM)
 $168,103 NSA 5 Yr(s)
The role of mutated WNK1 (WNK1/HSN2) neuronal specific isoform in HSANII
SCHAFFER, Ayal
Sunnybrook Health Sciences Centre CAIRNEY, John / CHEUNG, Amy H / KURDYAK, Paul A / LEVITT, Anthony J
 $36,625 BSB 2 Yr(s)
An Epidemiological Comparison of Bipolar Disorder and Major Depressive Disorder: Implications for Improving Diagnosis and Management
SEGUELA, Philippe A
McGill University $132,010 CP 5 Yr(s)
Physiologie moléculaire des récepteurs-canaux P2X dans les neurones de la douleur
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
72
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SHIZGAL, Peter
Concordia University (Montreal, Quebec) PENHUNE, Virginia B / PLOURDE, Gilles
 $120,770 BSA 5 Yr(s)
Neural correlates of thermal comfort and discomfort: functional magnetic resonance imaging.
SOMA, Kiran K
University of British Columbia $135,929 BSA 5 Yr(s)
Neuroendocrine regulation of aggressive behaviour and adult neuroplasticity
SOSSI, Vesna
University of British Columbia FLORESCO, Stanley B / MCKEOWN, Martin J / STOESSL, A. Jonathan / YOUNG, Allan H
 $96,896 BSB 3 Yr(s)
Investigation of treatment related compulsive behaviours and impulse control disorders in Parkinson's disease
ST-AMANT, Louis
Université de Montréal $87,229 NSB 5 Yr(s)
The genetic basis and role of spontaneous activity in vertebrate motor network development.
STANLEY, Elise F
University Health Network (Toronto) $138,906 NSB 5 Yr(s)
Toronto Western Research Institute (Toronto)
Nanophysiology of fast transmitter release.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
73
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
STANLEY, Elise F
University Health Network (Toronto) $165,442 NSA 5 Yr(s)
Toronto Western Research Institute (Toronto)
The Presynaptic Transmitter Release Site Organelle
STONE, Laura S
McGill University $100,403 PT 5 Yr(s)
Seven-transmembrane domain receptors in pain and analgesia: actions and interactions
TYNDALE, Rachel F
University of Toronto $178,880 PT 5 Yr(s)
Pharmacogenetics: CYP genetic variants alter smoking
VERGE, Valerie M
University of Saskatchewan $133,963 NSB 5 Yr(s)
Sensory neuron injury, repair and maladaptive consequences: Role of neurotrophins
WANG, Yu Tian
University of British Columbia $139,556 NSA 5 Yr(s)
Investigation into molecular mechanisms and physiological roles of activity-dependent AMPA receptor insertion
WEEN, Jon E
Baycrest Centre for Geriatric Care (Toronto) ALEXANDER, Michael P / STUSS, Donald T
 $35,111 BSC 2 Yr(s)
Fractionated frontal and executive function as a function of deep white matter stroke.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
74
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Neurosciences, Mental Health and Addiction / Neurosciences, santé mentale et toxicomanies
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
WILD, Cameron T
University of Alberta REHM, Juergen T / RUSH, Brian R / SOMERS, Julian / URBANOSKI, Karen A
 $149,494 PSB 3 Yr(s)
Social control and coercion in addiction treatment
WILSON, Alan A
MIZRAHI, Romina ADDINGTON, Jean M / HOULE, Sylvain / RUSJAN, Pablo M
 $138,226 BSB 3 Yr(s)
Centre for Addiction and Mental Health (Toronto)
Stress-induced dopamine release in subjects at clinical high risk for psychosis: a [11C]-(+)- PHNO PET study
YANG, Jaynie F
GORASSINI, Monica A NORTON, Jonathan $116,913 MOV 3 Yr(s)
University of Alberta
Retraining walking after incomplete spinal cord injury
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
75
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
AGELLON, Luis B
McGill University $114,088 NUT 3 Yr(s)
Factors controlling nutrient assimilation
BAKOVIC, Marica
University of Guelph $110,628 M 5 Yr(s)
Targeted disruption and regulation of the CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) gene
BALLERMANN, Barbara J
University of Alberta LUYCKX, Valerie A $147,911 EM 5 Yr(s)
Glomerular Endothelial Cell Development and Differentiation
BELSHAM, Denise D
University of Toronto $158,154 M 5 Yr(s)
Sensing of peripheral nutrient status by the hypothalamus.
BICHET, Daniel-Georges
Hôpital du Sacré-Coeur de Montréal PETERSON, Alan C $111,980 EM 3 Yr(s)
A transgenic approach for the study of the expression and regulation of the human AVPR2 gene
BRUNTON, Janet A
Memorial University of Newfoundland $83,722 NUT 3 Yr(s)
Dipeptides as trophic factors in the gastrointestinal tract
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
76
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
CARPENTIER, André C
Université de Sherbrooke $139,976 M 3 Yr(s)
Centre hospitalier universitaire de Sherbrooke
Investigation of postprandial fatty acid metabolism in the natural history of type 2 diabetes mellitus (T2DM)
CEDDIA, Rolando
York University (Toronto, Ontario) $113,534 M 3 Yr(s)
Regulation of white adipose tissue metabolism by AMPK
CORNELL, Rosemary B
Simon Fraser University (Burnaby, B.C.) $127,645 BMA 5 Yr(s)
Cytidylyltransferase - membrane interactions: Reciprocal effects on the protein and the membrane
COUTURE, Patrick
Université Laval LAMARCHE, Benoît / VOHL, Marie-Claude
 $94,650 NUT 3 Yr(s)
Effects of n-3 polyunsaturated fatty acids on chylomicron secretion and expression of genes that regulate intestinal lipid metabolism in men with type 2 diabetes
DESNOYERS, Serge
Université Laval BAZIN, Richard / GUERIN, Sylvain L
 $108,895 CIA 3 Yr(s)
Centre hospitalier de l'Université Laval (Québec)
Expression of the human PARP-1/PARG genes and poly(ADP-ribose) metabolism in diabetic retinopathy
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
77
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
DIONNE, Isabelle
Université de Sherbrooke AUBERTIN, Mylene / BROCHU, Martin / KHALIL, Abdelouahed
 $141,338 NUT 3 Yr(s)
Centre de recherche sur le vieillissement (QC)
Aerobic exercise and phytoestrogens: a synergistic effect on factors predisposing to CVD in postmenopausal women
DROUIN, Jacques
Institut de recherches cliniques de Montréal BALSALOBRE, Aurelio / VALLETTE-KASIC, Sophie
 $174,008 E 5 Yr(s)
Regulatory mechanisms for differentiation of pituitary POMC cells
DUBOIS, Lise
University of Ottawa POTVIN KENT, Monique C
 $82,706 NUT 3 Yr(s)
Television food advertising, obesity and food intake in anglophone and francophone children in Ontario and Quebec
ELLIOTT, Charlene D
University of Calgary $44,947 NUT 3 Yr(s)
Food marketing and childhood obesity: Assessing child and parental responses to 'fun foods'
GAISANO, Herbert Y
University of Toronto $114,294 M 5 Yr(s)
Rescuing insulin exocytotic defects in type 2 diabetes
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
78
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
HADDAD, Elie
Hôpital Sainte-Justine (Montréal) LE DEIST, Francoise L / PSHEZHETSKY, Alexey V
 $97,564 EM 3 Yr(s)
Study of the mechanisms of idiopathic nephrotic syndrome by using a new mouse model of the disease obtained by humanizing NOD/SCID mice with patients' CD34+ cells.
HESS, David A
University of Western Ontario $110,139 E 4 Yr(s)
Formation of a regenerative niche for the endogenous recovery of beta-cell function.
HOLLOWAY, Alison C
McMaster University GERSTEIN, Hertzel C / MORRISON, Katherine Mary / TARNOPOLSKY, Mark A
 $103,873 CIA 5 Yr(s)
In utero exposure to nicotine and postnatal health consequences: Mechanisms of dysglycemia
JOHNSON, James D
University of British Columbia $119,985 M 3 Yr(s)
Intracellular calcium stores as master regulators of pancreatic beta-cell survival: Studies on transplantable human islets and knockout mice
JOSEPH, Jamie W
University of Waterloo (Ontario) $85,512 M 3 Yr(s)
Novel pathways in the metabolic regulation of insulin release from pancreatic beta-cells.
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
79
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
KAPUS, Andras
St. Michael's Hospital (Toronto) $123,564 CBM 5 Yr(s)
Myocardin-related transcription factor: a central regulator of epithelial-myofibroblast transition
LAM, Tony K
University Health Network (Toronto) $119,335 M 5 Yr(s)
CNS Nutrient Sensing, Food Intake and Glucose Homeostasis
MARCEL, Yves L
University of Ottawa $133,388 M 5 Yr(s)
University of Ottawa Heart Institute
Apolipoprotein A-I lipidation and HDL genesis
PANTOPOULOS, Konstantinos
Jewish General Hospital (Montreal) $128,656 EM 5 Yr(s)
Lady Davis Institute for Medical Research (Mtl)
Iron metabolism in health and disease: The IRE/IRP system and beyond
PANTOPOULOS, Konstantinos
Jewish General Hospital (Montreal) $154,672 CBM 3 Yr(s)
Lady Davis Institute for Medical Research (Mtl)
The role of soluble hemojuvelin in systemic iron homeostasis
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
80
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
PIN, Christopher L
University of Western Ontario $127,480 CBM 5 Yr(s)
Signaling networks in pancreatic disease
POITOUT, Vincent
Centre Hosp. de l'Université de Montréal (CHUM)
 $122,239 M 3 Yr(s)
The role of GPR40 and GPR120 in pancreatic beta-cell function
REIMER, Raylene A
University of Calgary $97,075 NUT 3 Yr(s)
Dietary modulation of integrated gut hormone response to manage obesity
ROSS, Robert M
Queen's University (Kingston, Ontario) ADAMS, Michael A / JANISZEWSKI, Peter M / MORALES, Alvaro / TSCHAKOVSKY, Michael E
 $100,977 GSH 3 Yr(s)
Acute and Chronic Exercise as Treatment Strategies for Erectile Dysfunction in Obese Men
ROZEN, Rima
The Research Institute of the McGill University Health Centre
 CHRISTENSEN, Karen E $86,000 NUT 2 Yr(s)
Trifunctional folate-metabolizing enzyme MTHFD1: impact on birth defects and cancer
SHARKEY, Keith A
University of Calgary DAVISON, Joseph S / PATEL, Kamala D / PITTMAN, Quentin J
 $125,054 EM 5 Yr(s)
Endocannabinoids in the regulation of gastrointestinal motor function
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
81
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
SINGH, Gurmit
McMaster University GERSTEIN, Hertzel C / LAFLAMME, Pierre / PINTHUS, Jehonathan H
 $120,400 PS 5 Yr(s)
Juravinski Cancer Centre (Hamilton, ON)
Reactive oxygen species: A link between hyperglycemia and cancer.
SONENBERG, Nahum
McGill University $159,361 CP 5 Yr(s)
Physiology of translational control by Paips - modulators of poly(A)-binding protein.
TUPLING, Allan R
University of Waterloo (Ontario) $60,000 MOV 2 Yr(s)
Effects of Altered Ca2+ Pumping Efficiency of Sarco(endo)plasmic Reticulum Ca2+-ATPases on Metabolic Rate and Muscle Contractile Function
VOLCHUK, Allen O
University Health Network (Toronto) $98,705 M 3 Yr(s)
The Role of ATF6 and OASIS Endoplasmic Reticulum Stress Signaling Pathways in Pancreatic beta-Cells
WRIGHT, David
University of Alberta $60,228 NUT 3 Yr(s)
Control of adipose tissue mitochondrial content
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
82
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Nutrition, Metabolism and Diabetes / Nutrition, métabolisme et diabète
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ZHANG, Shao-Ling
Centre Hosp. de l'Université de Montréal (CHUM)
 CHAN, John S $104,036 EM 3 Yr(s)
Maternal Diabetes, Reactive Oxygen Species, Nephrogenesis and Perinatal Programming
ZWINGMANN, Claudia
Centre Hosp. de l'Université de Montréal (CHUM)
 $78,492 EM 3 Yr(s)
Studies on the role of glutamine synthetase nitration in Hepatic Encephalopathy following acute failure
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
83
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Population and Public Health / Santé publique et des populations
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
ANIS, Aslam H
University of British Columbia FISCHER, Benedikt / MACNAB, Ying C / MARSH, David C / NOSYK, Bohdan P / SCHECHTER, Martin T
 $47,850 POP 2 Yr(s)
An evaluation of long-term medical outcomes following discontinuation of methadone maintenance treatment
ASBRIDGE, Mark
Dalhousie University (Nova Scotia) CHISHOLM, Douglas / CUSIMANO, Michael D / MAGEE, Kirk D / MANN, Robert E / MURPHY, Nancy / REHM, Juergen T / TALLON, John M
 $218,122 BSB 3 Yr(s)
Cannabis and traffic collisions: A case crossover study of patients presenting to tertiary care centres in Toronto and Halifax
BARNETT, Tracie A
Hôpital Sainte-Justine (Montréal) APPARICIO, Philippe P / DANIEL, Mark / GAUVIN, Lise / GRAY- DONALD, Katherine A / KESTENS, Yan / KOUSHIK, Anita / LAMBERT, Marie / LEFFONDRE, Karen / MCGRATH, Jennifer J
 $82,224 POP 3 Yr(s)
Investigating the role of the built environment in the development and maintenance of excess weight in a cohort of children at risk for obesity
BERNSTEIN, Charles N
University of Manitoba BLANCHARD, James F / GRAFF, Lesley A / LESLIE, William D / LIX, Lisa M / LONGOBARDI, Teresa / VAGIANOS, Kathy / WALKER, John R
 $301,358 PUB 5 Yr(s)
Understanding the biological, clinical, and psychosocial determinants of health outcomes in inflammatory bowel disease: A research program
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
84
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Population and Public Health / Santé publique et des populations
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
BROPHY, James M
McGill University DENDUKURI, Nandini / ETMINAN, Mahyar / LEVESQUE, Linda E
 $87,300 POP 2 Yr(s)
A pharmacoepidemiology study of the cardiovascular safety of bisphosphonates.
CSIZMADI, Ilona
ROBSON, Paula J BRYANT, Heather E / FRIEDENREICH, Christine M / JONES, Peter J / KOPCIUK, Karen A / LAU, David C / YASUI, Yutaka
 $95,268 PUB 2 Yr(s)
6 Mths
Alberta Cancer Board (Edmonton)
Alberta Cancer Board (Calgary)
Development of a multidimensional measure of activity energy expenditure for use in large populations.
DUNN, James R
St. Michael's Hospital (Toronto) HWANG, Stephen W / JANUS, Magdelena / MATHESON, Flora I / MOINEDDIN, Rahim / MUNTANER, Carles / O'CAMPO, Patricia
 $223,959 POP 5 Yr(s)
Effects of social housing on adult and child mental health: A prospective study in the GTA west
HAYNES, Robert B
McMaster University MCKIBBON, Kathleen Ann
 $130,185 KTE 3 Yr(s)
Clinical search retrieval and dissemination from large internet databases such as MEDLINE
* "Research Institution" is displayed only when it is different from "Institution Paid".
** PRC = Peer Review Committee. A legend to the committee codes appears at the end of this list.
85
Results of the 15/09/2007 200709MOP Operating Grant Competition
Updated : 12/03/2009
Primary Institute : Population and Public Health / Santé publique et des populations
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual
Operating Amount
 Equipment PRC** Term Status
HWANG, Stephen W
AUBRY, Tim D
DUNN, James R / HOCH, Jeffrey S / HUBLEY, Anita M / HULCHANSKI, J. D / KLODAWSKY, Fran / NISENBAUM, Rosane
 $400,618 POP 4 Yr(s)
FARRELL, Susan J
PALEPU, Anita
St. Michael's Hospital (Toronto)
The Health and Housing in Transition (HHiT) Study: A Longitudinal Study of the Health of Homeless and Vulnerably Housed Adults in Vancouver, Toronto, and Ottawa
KELEMEN, Linda E
Alberta Cancer Board (Edmonton) BROOKS-WILSON, Angela R / COOK, Linda S / LE, Nhu D
 $161,319 POP 3 Yr(s)
Alberta Cancer Board (Calgary)
Genetic variation in the one carbon transfer pathway and ovarian cancer risk: a replication- association study
KIRBY, Gordon M
University of Guelph $88,758 PS 3 Yr(s)
Role of glutathione transferases in stress cell signaling
LIX, Lisa M
University of Manitoba BOWMAN, Christopher S / HOBSON, Douglas E / LESLIE, William D / QUAN, Hude / ROOS, Leslie L / TARGOWNIK, Laura E / WANG, Liqun
 $67,945 PUB 3 Yr(s)
Classification Algorithms to Distinguish Chronic Disease Cases from Non-Cases in Administrative Data