Regenerative Medicine and Nanomedicine Initaitive
Team Grants and New Discoveries: High-Risk Seed Grants (June 2005 RFA)
The Regenerative Medicine and Nanomedicine Initiative is one of the four main CIHR large initiatives. The fundamental goal of this initiative is the development of meaningful multi-disciplinary research approaches to regenerative medicine and nanomedicine. This necessitates the continued integration of the physical, engineering, computational and chemical sciences, among others, with the health sciences. These approaches need to balance consideration of the social, cultural and ethical impacts of these novel technologies with key rehabilitation and accessibility issues, as well as the potential economic costs of such treatments. Research into the maintenance of health or prevention of disease and degeneration is also encompassed by this initiative. The commitment to supporting truly innovative and leading edge multi-disciplinary research directed against key health research problems makes up the core of this strategic initiative.
The June 2005 RFA in Regenerative Medicine and Nanomedicine was a strategic initiative led by the CIHR Institute of Neurosciences, Mental Health and Addiction and the Institute of Genetics in partnership with: Institute of Aboriginal People's Health, Institute of Aging, Institute of Cancer Research, Institute of Circulatory and Respiratory Health, Institute of Infection and Immunity, Institute of Musculoskeletal Health and Arthritis, ALS Society of Canada, Canadian Space Agency, Canadian Stroke Network, Jacob's Ladder, Juvenile Diabetes Research Foundation International, Ontario Neurotrauma Foundation, The Foundation for Fighting Blindness and the Stem Cell Network.
The June 2005 RFA offered support for innovative research projects in the areas of Nanomedicine and Technology Development, Gene Therapy, Stem Cells, Tissue Engineering and Rehabilitation Sciences. This support was provided through innovative Team Grants and New Discoveries: High-Risk Seed Grants.
Team Grants
The objectives of the Team Grant are to:
- supply support funds for the creation or development of competitive research teams, which show
- potential for successfully applying for infrastructure team funding in the future;
- support multidisciplinary research in identified areas of focus;
- support the training and establishment of new investigators in identified areas of focus;
- create a team environment to favour the development of new fundable research projects
New Discoveries: High-Risk Seed Grants
The purpose of the New Discoveries: High-Risk Seed Grants program is to encourage novel, innovative, and inventive research. Successful applications will be unique, original, and /or extraordinary but of excellent quality and potential. The proposals are expected to:
- Be clearly novel, innovative, inventive and exciting to peer reviewers despite their inherent risk.
- Demonstrate the potential for significant impact.
- Facilitate the rapid transfer of research findings through appropriate communication strategies.
The applications approved for funding through the Regenerative Medicine and Nanomedicine: Initiative are listed below.
| Results of the Strategic Initiative | Applications Received | Applications Approved |
|---|---|---|
| Team Grants | 25 | 7 |
| High Risk Seed Grants | 38 | 8 |
Team Grants
| Principal Investigators Institution Paid Title |
Co-Applicant (s) | Average Annual Operating Amount | Term | Funding by |
|---|---|---|---|---|
| CARBONETTO, Salvatore McGill University Reorganization of Brain Micorcircuits |
ROULEAU, Guy;VAN MEYEL, Donald;RAO, Yong;CHANG, Chieh;MCKINNEY, Rebecca;MURAI, Keith;COSSETTE, Patrick;JUNCKER, David; | $350,000 | 5 years | CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG) |
| FOLDVARI, Marianna University of Waterloo Design and development of targeted gene delivery systems |
NAZARALI, Adil; HAAS, Thomas; GROCHULSKI, Pawel; HULL, Peter; | $300,000 | 5 years | CIHR / Institute of Genetics (IG) / Institute of Musculoskeletal Health and Arthritis (IMHA) |
| KANDEL, Rita Mount Sinai Hospital Repair of Early Joint Damage - A Tissue Engineering Approach |
ERKORKMAZ, Kaan; GRYNPAS, Marc; HURTIG, Mark; PAPINI, Marcello; NAGY, Andras; STANFORD, William; GROSS, Allan; PILLIAR, Robert; TOYSERKANI, Ehsan; WALDMAN, Stephen; WHITE, Lawrence; ZALZAL, Paul. | $422,315 | 5 years | CIHR / Institute of Aging (IA) / Institute of Musculoskeletal Health and Arthritis (IMHA) / Institute of Genetics (IG) |
| PIRET, James University of British Columbia Analysis of Stem Cells Using a New High-Throughput Technology for Interrogating the Molecular Responses of Single Cells |
EAVES, Connie; HANSEN, Carl; HUMPHRIES, Richard | $409,199 | 5 years | CIHR / Institute of Genetics (IG) |
| RANCOURT, Derrick University of Calgary Stem Cells as Promoters of Skeletal Repair |
MATYAS, John; KALLOS, Michael;ZUR NIEDEN, Nicole; HALLGRIMSSON, Benedikt;DUNN, Jeffrey; UNDERHILL, Tully;ULUDAG, Hasan; MULDREW, Kenneth;DUNCAN, Neil;ZERNICKE, Ronald; BOYD, Steven; AUBIN, Jane | $297,000 | 5 years | CIHR / Institute of Genetics (IG) / Institute of Musculoskeletal Health and Arthritis (IMHA) |
| WEISEL, Richard University Health Network The cardiac regeneration project: Quantitative cell tracking and response for cardiac regenerative approaches (CARE Project) |
LI, Ren-Ke; SEFTON, Michael; JAFFRAY, David; WILSON, Brian; NEVEROVA, Irina | $436,510 | 5 years | CIHR |
| ZOCHODNE, Douglas University of Calgary Dynamic manipulation of nerve regeneration: An "electronic-axon interface" |
MIDHA, Rajiv; JULLIEN, Graham; SYED, Naweed; VERGE, Valerie; GORDON, Tessa; CHAN, Kam Ming | $450,000 | 5 years | CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG) |
High Risk Seed Grants
| Principal Investigators Institution Paid Title |
Co-Applicant (s)/ | Average Annual Operating Amount | Term | Funding by/ |
|---|---|---|---|---|
| FANG, Qiyin McMaster University Development of a multiplexing confocal fluorescence lifetime imaging microscope for high speed molecular nano-imaging of drug interactions in cancer cells |
ANDREWS, David | $74,760 | 2 years | CIHR / Institute of Genetics (IG) |
| HU, Jim Hospital for Sick Children Generation of vector-specific tolerance for lung gene therapy |
$75,000 | 2 years | CIHR / Institute of Genetics (IG) / Institute of Infection and Immunity (III) | |
| JUNCKER, David McGill University Unraveling cues to neuronal regeneration by shaping the microenvironment of single growth cones in space and time using a microfluidic probe |
$61,689 | 2 years | CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG) | |
| LU, Qing-Bin University of Waterloo Development of a single-photon NIR photodynamic therapy through time-resolved femtosecond laser spectroscopic studies of mechanisms of drug action at the molecular level |
STRICKLAND, Donna; CAMPBELL, Melanie | $75,000 | 2 years | CIHR / Institute of Genetics (IG) |
| NADEAU, Jay Louise McGill University Selected targeting and destruction of malignant cells using redox-sensitive quantum dots |
HOLLMANN, Caroline | $73,850 | 2 years | CIHR / Institute of Genetics (IG) |
| O'CONNOR, Timothy University of British Columbia Development of a high throughput screen for bioactive compounds that stimulate neural regeneration |
ANDERSON, Raymond | $70,492 | 2 years | CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG) |
| TRIFIRO, Marc Sir Mortimer B. Davis Jewish General Hospital The development of novel biosensors |
LAWRENCE, Marcus | $75,000 | 2 years | CIHR / Institute of Genetics (IG) |
| WALKER, Gilbert University of Toronto Near field chemical imaging and force spectroscopy of engineered tissue surfaces |
$75,000 | 2 years | CIHR / Institute of Genetics (IG) |
